Table 2 Cytokine secretion profile of mature DCs.
short-term IL-15 DCs | long-term IL-15 DCs | IL-4 DCs | |||
|---|---|---|---|---|---|
cc-mDC | TLR-mDC | cc-mDC | TLR-mDC | cc-mDC | |
(pg/mL) | (pg/mL) | (pg/mL) | (pg/mL) | (pg/mL) | |
Typical T h 1-polarizing | |||||
IL-12p70 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
IFN-γ | 0 ± 0 | 3671 ± 394 | 0 ± 0 | 4510 ± 686 | 0 ± 0 |
IL-2 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Typical T h 2-polarizing | |||||
IL-4 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
IL-5 | 9 ± 5 | 6 ± 6 | 0 ± 0 | 0 ± 0 | 11 ± 6 |
IL-10 | 0 ± 0 | 4 ± 4 | 0 ± 0 | 50 ± 50 | 0 ± 0 |
Pro-inflammatory | |||||
TNF-α | 281 ± 124 | 1132 ± 551 | 1078 ± 268 | 4424 ± 1446 | 39 ± 16 |
TNF-β | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
IL-1β | 60 ± 55 | 0 ± 0 | 146 ± 64 | 55 ± 33 | 71 ± 45 |
IL-6 | 1065 ± 102 | 8163 ± 3246 | 1660 ± 78 | 13391 ± 2732 | 793 ± 51 |
IL-8 | 9914 ± 986 | 6109 ± 2468 | 3876 ± 483 | 2061 ± 109 | 9495 ± 2289 |