Table 2 Immunohistochemical scores obtained from skin biopsies from xenografted SCID mice treated with vehicle, calcipotriol and betamethasone dipropionate (BDP).
Vehicle | calcipotriol | Betamethasone | ||||
|---|---|---|---|---|---|---|
n = 5 | n = 7 | p-value vs. vehicle | n = 4 | p-value vs. vehicle | p-value vs. calcipotriol | |
CD3 (number/mm2) | 391.4 ± 152.1 | 393.7 ± 230.5 | NS | 134.7 ± 55.6 | 0.007 | 0.025 |
CD4 (number/mm2) | 87.7 ± 110.7 | 67.6 ± 49.6 | NS | 5.8 ± 2.3 | NS | 0.016 |
CD8 (number/mm2) | 32.9 ± 27.1 | 36.6 ± 42.3 | NS | 9.7 ± 6.6 | NS | NS |
CD45RO (number/mm2) | 190.1 ± 191.1 | 172.1 ± 132.9 | NS | 103.3 ± 89.8 | NS | NS |
Ki-67 (number/mm) | 439.0 ± 278.0 | 362.8 ± 255.2 | NS | 147.8 ± 189.4 | NS | NS |
CK10 (% area) | 70.6 ± 21.0 | 73.0 ± 21.9 | NS | 75.7 ± 14.9 | NS | NS |
CK16 (% area) | 19.5 ± 13.5 | 11.9 ± 13.4 | NS | 7.9 ± 9.7 | NS | NS |
Epidermal thickness (μm) | 356.1 ± 121.4 | 225.9 ± 117.1 | NS | 98.1 ± 14.9 | 0.002 | 0.038 |