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Table 2 Immunohistochemical scores obtained from skin biopsies from xenografted SCID mice treated with vehicle, calcipotriol and betamethasone dipropionate (BDP).

From: Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

  Vehicle calcipotriol   Betamethasone   
  n = 5 n = 7 p-value vs. vehicle n = 4 p-value vs. vehicle p-value vs. calcipotriol
CD3 (number/mm2) 391.4 ± 152.1 393.7 ± 230.5 NS 134.7 ± 55.6 0.007 0.025
CD4 (number/mm2) 87.7 ± 110.7 67.6 ± 49.6 NS 5.8 ± 2.3 NS 0.016
CD8 (number/mm2) 32.9 ± 27.1 36.6 ± 42.3 NS 9.7 ± 6.6 NS NS
CD45RO (number/mm2) 190.1 ± 191.1 172.1 ± 132.9 NS 103.3 ± 89.8 NS NS
Ki-67 (number/mm) 439.0 ± 278.0 362.8 ± 255.2 NS 147.8 ± 189.4 NS NS
CK10 (% area) 70.6 ± 21.0 73.0 ± 21.9 NS 75.7 ± 14.9 NS NS
CK16 (% area) 19.5 ± 13.5 11.9 ± 13.4 NS 7.9 ± 9.7 NS NS
Epidermal thickness (μm) 356.1 ± 121.4 225.9 ± 117.1 NS 98.1 ± 14.9 0.002 0.038
  1. NS, not significant.