Vehicle | calcipotriol | Daivobet® | ||||
---|---|---|---|---|---|---|
n = 16 | n = 16 | p-value vs. vehicle | n = 16 | p-value vs. vehicle | p-value vs. calcipotriol | |
CD3 (number/mm2) | 351.7 ± 261.0 | 309.0 ± 199.0 | NS | 97.6 ± 72.5 | <0.001 | <0.001 |
CD4 (number/mm2) | 347.9 ± 221.7 | 289.2 ± 128.9 | NS | 104.2 ± 69.1 | 0.001 | 0.002 |
CD8 (number/mm2) | 156.0 ± 111.7 | 152.4 ± 113.3 | NS | 44.5 ± 30.2 | <0.001 | <0.001 |
CD45RO (number/mm2) | 419.0 ± 284.4 | 329.9 ± 201.7 | NS | 96.1 ± 70.4 | <0.001 | <0.001 |
Ki-67 (number/mm) | 258.5 ± 140.5 | 165.8 ± 107.5 | NS | 43.2 ± 25.7 | <0.001 | <0.001 |
CK10 (% area) | 64.2 ± 9.3 | 65.5 ± 10.7 | NS | 68.8 ± 13.3 | NS | NS |
CK16 (% area) | 21.4 ± 22.5 | 11.4 ± 15.7 | NS | 0.1 ± 0.4 | <0.001 | 0.028 |
Epidermal thickness (μm) | 191.0 ± 67.6 | 148.8 ± 63.4 | 0.01 | 66.5 ± 15.3 | <0.001 | <0.001 |
Strat corneum (extent) | 2.1 ± 1.0 | 1.0 ± 0.8 | 0.002 | 0.2 ± 0.4 | <0.001 | 0.005 |
Strat granulosum (extent) | 1.4 ± 1.4 | 0.4 ± 0.9 | 0.007 | 0.0 ± 0.0 | <0.001 | NS |
Parakeratosis (extent) | 1.6 ± 1.3 | 0.5 ± 0.9 | 0.002 | 0.0 ± 0.0 | <0.001 | 0.04 |
Infiltration (extent) | 1.5 ± 0.6 | 1.2 ± 0.4 | NS | 0.9 ± 0.3 | <0.001 | NS |