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Table 1 Immunohistochemical and histopathological scores obtained from skin biopsies from the psoriasis plaque test with treatments of vehicle, calcipotriol and Daivobet® ointment.

From: Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

 

Vehicle

calcipotriol

 

Daivobet®

  
 

n = 16

n = 16

p-value vs.

vehicle

n = 16

p-value vs.

vehicle

p-value vs.

calcipotriol

CD3 (number/mm2)

351.7 ± 261.0

309.0 ± 199.0

NS

97.6 ± 72.5

<0.001

<0.001

CD4 (number/mm2)

347.9 ± 221.7

289.2 ± 128.9

NS

104.2 ± 69.1

0.001

0.002

CD8 (number/mm2)

156.0 ± 111.7

152.4 ± 113.3

NS

44.5 ± 30.2

<0.001

<0.001

CD45RO (number/mm2)

419.0 ± 284.4

329.9 ± 201.7

NS

96.1 ± 70.4

<0.001

<0.001

Ki-67 (number/mm)

258.5 ± 140.5

165.8 ± 107.5

NS

43.2 ± 25.7

<0.001

<0.001

CK10 (% area)

64.2 ± 9.3

65.5 ± 10.7

NS

68.8 ± 13.3

NS

NS

CK16 (% area)

21.4 ± 22.5

11.4 ± 15.7

NS

0.1 ± 0.4

<0.001

0.028

Epidermal thickness (μm)

191.0 ± 67.6

148.8 ± 63.4

0.01

66.5 ± 15.3

<0.001

<0.001

Strat corneum (extent)

2.1 ± 1.0

1.0 ± 0.8

0.002

0.2 ± 0.4

<0.001

0.005

Strat granulosum (extent)

1.4 ± 1.4

0.4 ± 0.9

0.007

0.0 ± 0.0

<0.001

NS

Parakeratosis (extent)

1.6 ± 1.3

0.5 ± 0.9

0.002

0.0 ± 0.0

<0.001

0.04

Infiltration (extent)

1.5 ± 0.6

1.2 ± 0.4

NS

0.9 ± 0.3

<0.001

NS

  1. NS, not significant.