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Table 1 Immunohistochemical and histopathological scores obtained from skin biopsies from the psoriasis plaque test with treatments of vehicle, calcipotriol and Daivobet® ointment.

From: Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

  Vehicle calcipotriol   Daivobet®   
  n = 16 n = 16 p-value vs.
vehicle
n = 16 p-value vs.
vehicle
p-value vs.
calcipotriol
CD3 (number/mm2) 351.7 ± 261.0 309.0 ± 199.0 NS 97.6 ± 72.5 <0.001 <0.001
CD4 (number/mm2) 347.9 ± 221.7 289.2 ± 128.9 NS 104.2 ± 69.1 0.001 0.002
CD8 (number/mm2) 156.0 ± 111.7 152.4 ± 113.3 NS 44.5 ± 30.2 <0.001 <0.001
CD45RO (number/mm2) 419.0 ± 284.4 329.9 ± 201.7 NS 96.1 ± 70.4 <0.001 <0.001
Ki-67 (number/mm) 258.5 ± 140.5 165.8 ± 107.5 NS 43.2 ± 25.7 <0.001 <0.001
CK10 (% area) 64.2 ± 9.3 65.5 ± 10.7 NS 68.8 ± 13.3 NS NS
CK16 (% area) 21.4 ± 22.5 11.4 ± 15.7 NS 0.1 ± 0.4 <0.001 0.028
Epidermal thickness (μm) 191.0 ± 67.6 148.8 ± 63.4 0.01 66.5 ± 15.3 <0.001 <0.001
Strat corneum (extent) 2.1 ± 1.0 1.0 ± 0.8 0.002 0.2 ± 0.4 <0.001 0.005
Strat granulosum (extent) 1.4 ± 1.4 0.4 ± 0.9 0.007 0.0 ± 0.0 <0.001 NS
Parakeratosis (extent) 1.6 ± 1.3 0.5 ± 0.9 0.002 0.0 ± 0.0 <0.001 0.04
Infiltration (extent) 1.5 ± 0.6 1.2 ± 0.4 NS 0.9 ± 0.3 <0.001 NS
  1. NS, not significant.