Biomarker endpoints after treatment with vehicle (A, D, G and J), calcipotriol (B, E, H and K) and Daivobet® (C, F, I and L) in the psoriasis plaque assay. A-C: Masson-Trichrome (MT) staining showing epidermal hyperplasia. D-F: Proliferation of keratinocytes in stratum basale of epidermis (Ki-67). G-I: Immunohistochemical staining with a pan-T cell marker (CD3). J-L: Epidermal expression of keratin 16 show decrease after treatment with calcipotriol and is absent after treatment with Daivobet®.