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Table 2 Analysis of diagnostic sensitivity, selectivity and error for a panel consisting of CA19-9, OPN and CHI3L1 compared to CA19-9 alone.

From: Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis

Test Run*

Panel Sensitivity†

Panel Selectivity‡

Panel Error§

CA19-9 Sensitivity||

CA19-9 Selectivity**

CA19-9 Error††

1

0.92 (0.65 - 0.99)

0.88 (0.53 - 0.98)

0.10

0.92 (0.65 - 0.99)

0.88 (0.53 - 0.98)

0.10

2

1.00 (0.65 - 1.0)

0.69 (0.42 - 0.87)

0.10

0.33 (0.14 - 0.61)

0.75 (0.41 - 0.93)

0.50

3

1.00 (0.65 - 1.0)

0.69 (0.42 - 0.87)

0.10

1.00 (0.65 - 1.0)

0.62 (0.36 - 0.82)

0.25

4

1.00 (0.76 - 1.0)

0.88 (0.53 - 0.98)

0.05

0.92 (0.65 - 0.99)

1.00 (0.68 - 1.0)

0.05

5

1.00 (0.68 - 1.0)

0.92 (0.65 - 0.99)

0.15

1.00 (0.68 - 1.0)

0.83 (0.55 - 0.95)

0.10

6

0.89 (0.57 - 0.98)

0.82 (0.52 - 0.95)

0.05

0.89 (0.57 - 0.98)

0.45 (0.21 - 0.72)

0.35

7

0.75 (0.47 - 0.91)

0.75 (0.41 - 0.93)

0.05

0.67 (0.39 - 0.86)

0.75 (0.41 - 0.93)

0.30

8

1.00 (0.72 - 1.0)

0.80 (0.49 - 0.94)

0.10

0.90 (0.60 - 0.98)

0.80 (0.49 - 0.94)

0.15

9

1.00 (0.77 - 1.0)

0.71 (0.36 - 0.92)

0.10

0.69 (0.42 - 0.87)

1.00 (0.65 - 1.0)

0.20

10

0.78 (0.45 - 0.94)

1.00 (0.74 - 1.0)

0.10

0.67 (0.35 - 0.88)

0.91 (0.62 - 0.98)

0.20

Average

0.93

0.81

0.13

0.80

0.80

0.22

  1. *- One complete run of analysis, including random sample division into training, modeling, and test sets
  2. † - Sensitivity of logistic regression model prediction with CA19-9, OPN, and CHI3L1 as model terms. Parenthetical values represent the 95% CI.
  3. ‡ - Selectivity of logistic regression model prediction with CA19-9, OPN, and CHI3L1 as model terms. Parenthetical values represent the 95% CI.
  4. §- Frequency of combined false negative and false positive calls in 20 test samples using a logistic regression model with CA19-9, OPN, and CHI3L1 as model terms
  5. || - Sensitivity of logistic regression model prediction with CA19-9 alone as a model term. Parenthetical values represent the 95% CI.
  6. **- Selectivity of logistic regression model prediction with CA19-9 alone as a model term. Parenthetical values represent the 95% CI.
  7. †† - Frequency of combined false negative and false positive calls in 20 test samples using a logistic regression model with CA19-9 alone as a model term