A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study

Table 3 173 and -794 genotype and allele distribution in the study population.

	-173							-794											Haplotype
Study groups	Genotype				Allele			Genotype							Allele
	G/G	G/C	C/C	p =	G	C	p =	5/5	5/6	5/7	6/6	6/7	7/7	p =	5	6	7	p =	-173 C and -794 CATT₇ positive	-173 C and -794 CATT₇ negative	p =
Healthy Controls (n = 94)	63	28	3	0.67	154	34	0.859	4	25	8	39	18	0	0.123	41	121	26	0.0451
Abdominal surgery without infection or inflammation (n = 183)	123	54	6		300	66		7	55	7	75	35	4		76	240	50
Severe sepsis (n = 169)	106	60	3		272	66		15	50	18	54	28	4		98	186	54
Survivors sev. Sepsis (n = 91)	66	23	2	0.022	155	27	0.039	12	28	7	35	6	3	0.0016	59	104	19	0.0174	15	76	0.0005
Non-Survivors sev. Sepsis (n = 78)	40	37	1		117	39		3	22	11	19	22	1		39	82	35		32	46

The 169 patients with severe sepsis are separated by surviving or non-surviving in the lower two rows. Genotype and allele distribution of healthy controls, patients with abdominal surgery, and patients with severe sepsis were tested by chi square test. Survivors and non-survivors of severe sepsis were also tested by chi square and Fischer's exact test where applicable, results were Bonferroni corrected. Incidence of the alleles -173 C and -794 CATT₇ was associated with non-surviving severe sepsis (p = 0.0005, Fisher exact Test, RR = 1,806, CI: 1.337 to 2.439).

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