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Figure 5 | Journal of Translational Medicine

Figure 5

From: NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols

Figure 5

In vivo redox images of ovarian xenograft tumors in mice. A redox-sensitive probe (R2SSR2) was injected intratumorally (100 mM; 15 μl), then sequential images were obtained for 30 min. The EPR images show the probe distribution in the tumor, while the tumor itself is not visible. (A) Representative images of time-course of redox probe distribution in untreated A2780 WT and A2780 cDDP tumors, as well as in A2780 cDDP tumor treated with NCX-4040 (5 mg/kg, daily). (B) Total in vivo redox levels expressed as a percent of A2780 WT level. (C) Glutathione (GSH) levels in the tumors excised on day 19 post-inoculation. Data represent mean ± SD obtained from 4 mice/group. *p < 0.05 versus A2780 WT group. **p < 0.05 versus A2780 cDDP group. The results demonstrate that NCX-4040 depleted thiol levels in the cisplatin-resistant tumor.

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