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Figure 1 | Journal of Translational Medicine

Figure 1

From: NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols

Figure 1

Comparision of the structure and effect of NCX-4040 and NCX-4016 on cell viability. (A) Molecular structure of NCX-4040 (acetyloxy)benzoic acid 4-(nitrooxymethyl)phenyl ester) and NCX-4016 (2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester). The nitroaspirins consist of acetylsalicylate (aspirin) linked to a spacer moiety by an ester bond. An NO-releasing moiety (-ONO2) is attached to the spacer. (B) Effect of NCX-4040 and NCX-4016 (25 μM) on the viability of cisplatin-resistant human ovarian cancer cells (A2780 cDDP). The results show a dose-dependent cytotoxic effect, with NCX-4040 demonstrating a substantially higher effect compared to NCX-4016.

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