Skip to main content

Table 1 Table 1 - Physical properties of PAMAM and Gd-PAMAM dendrimer generations

From: Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells

Dendrimer generation (G) No. terminal amines Naked PAMAM molecular weight# (kD) Gd-PAMAM molecular weight (kD) Gd-DTPA conjugation (%) Molar relaxivity&(s/mM)
G1 8 1.43 5.63 67.1 9.8
G2 16 3.26 11.2 65.9 10.1
G3 32 6.91 18.6 47.7 10.4
Lowly
conjugated
G4
64 14.2 24.4 29.8 7.8
Standard
G4
64 14.2 39.8 47.5 12.2
G5 128 28.8 79.8 47.2 10.9
G6 256 58.0 133 39.9 10.6
G7 512 116 330 50.0 10.3
G8 1024 233 597 37.8 9.4
  1. #obtained from Dendritech, Inc.
  2. measured by MALDI-TOF MS unless noted otherwise
  3. measured by ADF STEM
  4. &molar relaxivity of Gd-DTPA measured to be 4.1