TY - JOUR AU - Brem, Harold AU - Golinko, Michael S. AU - Stojadinovic, Olivera AU - Kodra, Arber AU - Diegelmann, Robert F. AU - Vukelic, Sasa AU - Entero, Hyacinth AU - Coppock, Donald L. AU - Tomic-Canic, Marjana PY - 2008 DA - 2008/12/01 TI - Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF JO - Journal of Translational Medicine SP - 75 VL - 6 IS - 1 AB - Multiple physiologic impairments are responsible for chronic wounds. A cell line grown which retains its phenotype from patient wounds would provide means of testing new therapies. Clinical information on patients from whom cells were grown can provide insights into mechanisms of specific disease such as diabetes or biological processes such as aging. SN - 1479-5876 UR - https://doi.org/10.1186/1479-5876-6-75 DO - 10.1186/1479-5876-6-75 ID - Brem2008 ER -