Table 1 A list of animal injury and disease models where hESCs have been shown to be effective
CELL TYPE DEVELOPED | ANIMAL MODEL | REFERENCE |
|---|---|---|
Oligodenrocyte progenitor | Spinal cord injury induced mouse | Keirstead et al., 2005 [69]; Nakamura et al., 2005 [70] |
Cardiomyocytes | Rat, Swine, Mice | Laflamme et al., 2007 [71]; Leor et al., 1996 [72]; Kehat et al., 2004 [73]; Caspi et al., 2007 [74] |
Hepatocyte | CCl4-injured SCID mouse model | Seo et al., 2005 [75] |
Chondrocyte | Canine Spinal Fusion model | Muschler et al., 2003 [76] |
Endothelial cells | Surgical induction of hind limb ischemia in athymic mouse | Cho et al., 2006 [77] |
Neural precursors | Quinolinic acid (QA)-induced Huntington's disease (HD) model in rats | Song et al., 2007 [78] |
Pancreatic cells | Streptozotocin-treated diabetic mice | Shim et al., 2007 [79] |
Skeletal myoblasts | SCID/Beige mice | Barberi et al., 2007 [80] |
Neuroepithelial precursors and Dopaminergic neurons | Parkinsons disease rodent model | Sonntag et al., 2007 [81] Ben-Hur et al., 2004 [82] |
hESCs | Open neural tube defect (ONTD) model in chick embryos | Lee et al., 2006 [83] |
T lymphoid lineage | Engraftment into human thymic tissues in immunodeficient mice | Galic et al., 2006 [84] |