Skip to main content

Table 1 A list of animal injury and disease models where hESCs have been shown to be effective

From: Human embryonic stem cells: preclinical perspectives

CELL TYPE DEVELOPED ANIMAL MODEL REFERENCE
Oligodenrocyte progenitor Spinal cord injury induced mouse Keirstead et al., 2005 [69]; Nakamura et al., 2005 [70]
Cardiomyocytes Rat, Swine, Mice Laflamme et al., 2007 [71]; Leor et al., 1996 [72]; Kehat et al., 2004 [73]; Caspi et al., 2007 [74]
Hepatocyte CCl4-injured SCID mouse model Seo et al., 2005 [75]
Chondrocyte Canine Spinal Fusion model Muschler et al., 2003 [76]
Endothelial cells Surgical induction of hind limb ischemia in athymic mouse Cho et al., 2006 [77]
Neural precursors Quinolinic acid (QA)-induced Huntington's disease (HD) model in rats Song et al., 2007 [78]
Pancreatic cells Streptozotocin-treated diabetic mice Shim et al., 2007 [79]
Skeletal myoblasts SCID/Beige mice Barberi et al., 2007 [80]
Neuroepithelial precursors and Dopaminergic neurons Parkinsons disease rodent model Sonntag et al., 2007 [81] Ben-Hur et al., 2004 [82]
hESCs Open neural tube defect (ONTD) model in chick embryos Lee et al., 2006 [83]
T lymphoid lineage Engraftment into human thymic tissues in immunodeficient mice Galic et al., 2006 [84]