Gene expression profiling for molecular distinction and characterization of laser captured primary lung cancers

Table 3 Selection of significantly differentially expressed genes in squamous cell carcinomas focusing on proliferation, cell structure and oncogenesis.

Gene Symbol	Gene Name	Fold Change SCC vs. NT	q-value
Proliferation
RFC4	replication factor C (activator 4)	5.73	0.37
CCNB2	Cyclin B 2	4.34	0.37
PRC1	protein regulator of cytokinesis 1	3.54	1.21
CENPA	centromere protein A	3.29	0.61
MAD2L1	mitotic arrest deficient-like 1	3.20	0.61
CDK4	cyclin-dependent kinase 4	2.89	0.37
CDC2	cell division cycle 2	2.89	0.37
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta	2.67	1.21
PCNA	proliferating cell nuclear antigen	2.62	0.37
PIR51	RAD51 associated protein 1	2.48	0.61
HEC1	kinetochore associated 2	2.15	0.84
MSH6	mutS homolog 6	2.10	1.06
RFC5	replication factor C (activator 5)	2.09	0.37
CCNA2	Cyclin A 2	2.05	1.06
CCNA1	Cyclin A 1	0.57	0.61
cell structure
COL11A1	collagen, type XI, alpha 1	7.94	0.84
COL1A1	collagen, type I, alpha 1	3.24	1.21
TMSNB	thymosin, beta, 4X	3.24	2.53
COL5A2	collagen, type V, alpha 2	2.99	0.37
COL1A2	collagen, type I, alpha 2	2.89	0.84
PLS3	plastin 3	2.46	0.37
COL6A3	collagen, type VI, alpha 3	2.28	1.34
FSCN1	fascin, homolog 1	2.20	1.06
oncogenesis
NMB	glycoprotein (transmembrane) nmb	4.01	1.34
RANBP1	RAN binding protein 1	3.23	0.37
MAF	v-maf Avian Musculoaponeurotic Fibrosarcoma oncogene	2.63	1.34
RACGAP1	Rac GTPase activating protein 1	2.53	0.61
PTTG1	pituitary tumor-transforming 1	2.49	1.34
MYC	v-myc Avian Myelocytomatosis viral oncogene homolog	2.43	1.90
RALA	v-ral simian leukemia viral oncogene homolog A	2.42	1.34
RAP2B	Ras-Related Protein 2B	2.30	0.84
RAN	Ras-Related Nuclear Protein	2.02	1.90
KIT	v-KIT Hardy-Zuckerman 4 Feline Sarcoma viral oncogene homolog	0.46	0.37
RABL2B	Rab-like 2B	0.35	0.37
RABL2A	Rab-like 2A	0.33	1.34

ISSN: 1479-5876