Table 1 Classification of significantly deregulated lung cancer genes in comparison to normal lung tissue with respect to cancer subtype and biological functions.
functional class | Adenocarcinoma n = 205 | squamous cell carcinoma n = 335 | small cell lung cancer n = 404 | |||
|---|---|---|---|---|---|---|
proliferation | 1 gene ↑ | 1 gene ↓ | 41 genes ↑ |  | 56 genes ↑ | 1 gene ↓ |
DNA-repair |  | 1 gene ↓ | 8 genes ↑ |  | 14 genes ↑ |  |
oncogenes/tumor related genes | 1 gene ↑ | 11 genes ↓ | 9 genes ↑ | 11 genes ↓ | 13 genes ↑ | 10 genes ↓ |
cell adhesion | 3 genes ↑ | 6 genes ↓ | 2 genes ↑ | 6 genes ↓ | 8 genes ↑ | 7 genes ↓ |
cell structure | 7 genes ↑ | 20 genes ↓ | 14 genes ↑ | 15 genes ↓ | 19 genes ↑ | 18 genes ↓ |
metabolism | 11 genes ↑ | 25 genes ↓ | 34 genes ↑ | 26 genes ↓ | 22 genes ↑ | 38 genes ↓ |
immune system | 6 genes ↑ | 13 genes ↓ | 3 genes ↑ | 19 genes ↓ | 2 genes ↑ | 25 genes ↓ |
signal transduction |  | 13 genes ↓ | 7 genes ↑ | 3 genes ↓ | 18 genes ↑ | 10 genes ↓ |
transcription | 1 gene ↑ | 8 genes ↓ | 10 genes ↑ | 5 genes ↓ | 22 genes ↑ | 4 genes ↓ |
transport | 2 genes ↑ | 12 genes ↓ | 11 genes ↑ | 15 genes ↓ | 8 genes ↑ | 15 genes ↓ |
development | 1 gene ↑ | 9 genes ↓ | 5 genes ↑ | 6 genes ↓ | 12 genes ↑ | 4 genes ↓ |
calcium-binding | 3 genes ↑ | 4 genes ↓ |  | 3 genes ↓ |  | 4 genes ↓ |
apoptosis |  | 1 gene ↓ |  |  | 3 genes ↑ | 1 gene ↓ |
unknown | 7 genes ↑ | 38 genes ↓ | 28 genes ↑ | 54 genes ↓ | 26 genes ↑ | 44 genes ↓ |