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Figure 3 | Journal of Translational Medicine

Figure 3

From: "Sequencing-grade" screening for BRCA1 variants by oligo-arrays

Figure 3

(A) – Heat map summarizing results for fragment 4 from 85 patients with breast cancer tested for BRCA1 mutation at the Bari National Cancer Institute. In red are identified SNPs which are annotated at the top of each column. Each row represents a patient's sample. The two cases highlighted in yellow refer to two patients whose array-based analysis could not be confirmed by sequencing due to insufficient DNA. Cases are self organized using Eisen's cluster program according to individual proximity to each other (Pearson's correlation). The yellow symbols (Star, Hexagon, Square) recall the cases shown in Figure 2. (B) Blow up of a graphical representation in fragment 4 of balanced hybridization between identical test and reference samples (top panel), a heterozygous (middle panel) and a homozygous (bottom panel) difference. SNPs in the test sample are shown as gain of signal in red while loss of signal in the consensus wild type signal is reflected by the four green probes. To the side is the region is represented as a scatter plot and as an actual image from the array.

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