Table 2 Recent evidence for indirect immunomodulatory mechanisms of HDI
From: Adjuvant therapy of melanoma with interferon: lessons of the past decade
Increase in Tumor Infiltrating cells36 |
|---|
Development of autoantibodies and clinical manifestations of autoimmunity (~30%)37,38 |
Decrease in Circulating Treg cells51 |
Modulation of the STAT1/STAT3 balance in tumor cells and host lymphocytes52 |
Change in serum cytokine concentrations53 |
Normalization of T cell STAT 1 signaling defects in peripheral blood lymphocytes54 |