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Table 2 Toxicities associated with DC/Apo-Nec vaccination (*)

From: A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10 -1082 promoter genotype as predictor of disease progression

Symptoms DC/Apo-Nec 5 × 106 DC/Apo-Nec 10 × 106 DC/Apo-Nec 15 × 106 DC/Apo-Nec 20 × 106
Fatigue 1/4 1/3 0/4 0/4
Headache 1/4 0/3 0/4 0/4
Chills 1/4 0/3 0/4 0/4
Abdominal cramps 0/4 0/3 0/4 1/4
Local reaction 4/4 3/3 4/4 4/4
Astenia 0/4 1/3 0/4 0/4
Nausea 0/4 0/3 0/4 1/4
Abdominal pain 0/4 0/3 0/4 1/4
Vomiting 0/4 0/3 0/4 1/4
Anorexia 0/4 1/3 0/4 0/4
Diarrea 0/4 0/3 0/4 1/4
Myalgia 1/4 0/3 1/4 0/4
  1. (*) Toxicity was Grade 1 in all cases.