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Table 2 Toxicities associated with DC/Apo-Nec vaccination (*)

From: A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10 -1082 promoter genotype as predictor of disease progression

Symptoms

DC/Apo-Nec 5 × 106

DC/Apo-Nec 10 × 106

DC/Apo-Nec 15 × 106

DC/Apo-Nec 20 × 106

Fatigue

1/4

1/3

0/4

0/4

Headache

1/4

0/3

0/4

0/4

Chills

1/4

0/3

0/4

0/4

Abdominal cramps

0/4

0/3

0/4

1/4

Local reaction

4/4

3/3

4/4

4/4

Astenia

0/4

1/3

0/4

0/4

Nausea

0/4

0/3

0/4

1/4

Abdominal pain

0/4

0/3

0/4

1/4

Vomiting

0/4

0/3

0/4

1/4

Anorexia

0/4

1/3

0/4

0/4

Diarrea

0/4

0/3

0/4

1/4

Myalgia

1/4

0/3

1/4

0/4

  1. (*) Toxicity was Grade 1 in all cases.