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Table 1 Characteristics of the patients participating in the Clinical Study

From: A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10 -1082 promoter genotype as predictor of disease progression

Pt #

Sex

Age

Stage

Mts Site

MN Cells obtained (×109cells)

Dose of DC/Apo-Nec (×106cells)

No. Vacc

Clin. Evolution (12/1/07)

IL-10 Promoter Genotype

1

F

42

III

LN

3.5

5

4

P (10 m)

AA

2

F

57

III

ND

3.6

5

4

NED (62 m+)

AG

3

M

32

III

ND

3.3

5

4

NED (43 m+)

AA

4

F

17

III

ND

4.4

5

4

NED (53 m+)

AG

5

M

56

IV

L,SC

5

10

4

P (4 m)

AA

6

M

60

III

ND

1.5

3

4

NED (45 m+)

AA

7

M

27

IV

SC

4.2

10

2

WP (1 m)

AA

8

M

26

IV

ND

3.6

10

4

P (7 m)

AA

9

F

42

III

ND

7.5

15

4

NED (79m+)

AG

10

M

34

IV

LN

6.2

15

4

P (11 m)

AG

11

M

44

IV

L

4.7

15

4

P (4 m)

AG

12

M

56

III

ND

8

15

4

NED (33m+)

AG

13

M

47

IIC

ND

9.3

20

4

NED (34 m+)

AA

14

M

30

III

ND

7.5

20

4

NED (47 m+)

GG

15

M

52

IV

LN

6

20

4

P (10 m)

AA

16

F

57

IV

SC

8.2

20

4

P(6 m)

AA

  1. ND: non-detectable disease after surgery; SC: subcutaneous; L: Lung; LN: Lymph node; NED: non-evident disease; P: progression; D: deceased. WP: withdrawn from protocol. m: months of follow-up from last surgery.