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Table 1 Perfusion Overview

From: Ex Vivo Metrics™, a preclinical tool in new drug development

Organs Blood Input Acceptance Criteria Dosing Routes Samples for Analysis
Lungs • Pulmonary artery
• Bronchial artery
• Perfusion pressures
• Flow rates
• Compliance
• Resistance
• Airway pressures
• Blood chemistry and biochemistry
• Airways
• Blood
• Blood/plasma
• Airway lavage
• Biopsies
Liver • Portal vein
• Hepatic artery
• Perfusion pressures
• Flow rates
• Bile flow
• Blood chemistry and biochemistry
• Blood • Blood/plasma
• Bile
• Biopsies
Intestine • Superior mesenteric artery (or its branches) • Perfusion pressure
• Flow rate
• Active peristalsis
• Blood chemistry and biochemistry
• Gut lumen
• Blood
• Blood/plasma
• Gut contents
• Biopsies