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Figure 2 | Journal of Translational Medicine

Figure 2

From: Allogeneic endometrial regenerative cells: An "Off the shelf solution" for critical limb ischemia?

Figure 2

Limb preservation by ERC administration. 16 BALB/c female mice (6–8 weeks of age, Jackson Labs, Bar Harbor, Maine) underwent unilateral ligation of the femoral artery and its branches (superficial eplgastrlc artery) for induction of the limb ischemia. Additionally, ligation of N. peroneus for reproducing a neurotrophic ulcer-like injury was performed. Mice were divided into 2 groups of 8. Immediately after induction of injury, 1 million ERC were injected into the hind-limb muscle below the area of ligation. Cells were also injected on day 0, day 2 and day 4. ERC where injected in a volume of 200 microliters of saline. By day 14, necrosis was observed in legs of 8 control mice. 8 mice treated with ERC had intact limbs, with 2 displaying signs of impeded walking.

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