Figure 2

Comparison between different drug schedules. Dashed line: activity observed 72, 96 and 120 h after a 1-h exposure to low Doc concentrations (0.001, 0.01 and 0.1 μM in diagrams A, B and C, respectively). Solid line: activity detected after a 72-, 96- and 120-h continuous exposure to Zol 100 μM. Dotted line: activity observed after a 1-h concomitant exposure to Zol 100 μM and low Doc concentrations (0.001, 0.01 and 0.1 μM, in diagrams A, B and C, respectively) followed by prolonged exposure to Zol 100 μM. Dash-dotted line: activity observed after prolonged exposure to Zol 100 μM followed by a 1-h concomitant exposure to Zol 100 μM and low Doc concentrations (0.001, 0.01 and 0.1 μM, in diagrams A, B and C, respectively). Error bars represent the mean standard deviation.