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Table 1 Relationship between bFGF level and paclitaxel activity: Comparison of image analysis and visual scoring results. The linear regression relationships between bFGF levels and the antiproliferation effect of paclitaxel (measured as EMAX and IC30) were analyzed using SAS. p-values indicate probability associated with r2. The 95% confidence interval (95% CI) around r2 is approximated as described previously [22].

From: Quantitative image analysis of intra-tumoral bFGF level as a molecular marker of paclitaxel resistance

Antiproliferation effect of paclitaxel Relationship between bFGF level and chemosensitivity
  r2 p-value 95% CI around r2
E MAX
Image Analysis 0.208 < 0.0001 0.074–0.370 §
Visual scoring 0.094 < 0.0001 0.011–0.236 §
IC 30
Image Analysis 0.317 < 0.0001 0.160–0.478*
Visual scoring 0.084 < 0.01 0.007–0.222*
  1. § The r2 for image analysis showed a trend of being higher than the r2 for pathological scoring (p = 0.11).
  2. * The r2 for image analysis (0.317) were outside the 95% CI for pathological scoring (0.007–0.222), indicating a statistically significant improvement in correlation using image analysis (p < 0.05).
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Journal of Translational Medicine

ISSN: 1479-5876

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