Skip to main content

Table 2 Serum biochemical analyses in four GRMD dogs under hIDPSC therapy (MT1, MT2, FT1 and FT2) and matched age control (MC and FC).

From: Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?

ANIMALS 30 days CK (U/L) ALT (U/L) FA (U/L) Urea (mg/dL) Creat (mg/dL) RBC (mlh/mm3) Ht (%) Hb (g/dL) WBC (mil/mm3)
Reference values* 0–200 until 50 until 130 until 40 until 1.5 – 2 3.5 – 6 26 – 39 8.5 – 13 8,5 – 17,3
FC 9,275 162 500 31 1 3.3 27 7.1 19,300
FT1-S 9,274 159 478 28.6 1 3.6 25 7.6 26,300
FT2-IM 4,647 134 352 22 0.98 4 26 8.8 32,000
MC 3,618 110 260 32.8 1 4.2 30 8.8 32,300
MT1-S 7,716 230 174 30 1 4.6 34 11 24,800
MT2- IM 5,668 163 217 32.9 1.1 4.7 33 11.5 23,600
ANIMALS 75 days CK (U/L) ALT (U/L) FA (U/L) Urea (mg/dL) Creat (mg/dL) RBC (mlh/mm 3 ) Ht (%) Hb (g/dL) WBC (mil/mm 3 )
FC 32,599 294 300 46 0.85 4.8 29 9.2 28,200
FT1-S 15,100 245 161 43.5 0.92 4.3 26 8.7 34,800
FT2-IM 24,784 192 117 37.8 0.9 4.6 28 9.2 30,200
MC 15,257 189 138 37.8 0.9 4.1 27 8.9 36,600
MT1-S 30,729 293 181 42.8 0.94 4.6 29 9.9 25,900
MT2- IM 15,291 237 191 46.9 0.92 4.6 28 9.7 39,100
ANIMALS 180 days CK (U/L) ALT (U/L) FA (U/L) Urea (mg/dL) Creat (mg/dL) RBC (mlh/mm 3 ) Ht (%) Hb (g/dL) WBC (mil/mm 3 )
Reference values* 0–200 until 50 until 130 until 40 until 1.5 – 2 5.5 – 7 34 – 40 11 – 15.5 8 – 16,000
FC 56,736 416 58 40 0.4 5.5 39 12.4 16,200
FT1-S 48,960 396 28 23 0.5 5.4 38 12.1 15,500
FT2-IM 51,296 228 8 38 0.4 6.0 39 13.1 14,100
MC 56,736 524 91 51 0.5 5.6 37 12 20,400
MT1-S 25,632 440 66 55 0.4 5.5 36 12.5 18,600
MT2- IM 36,512 500 62 40 0.4 5.5 38 12 15,600
ANIMALS 360 days CK (U/L) ALT (U/L) FA (U/L) Urea (mg/dL) Creat (mg/dL) RBC (mlh/mm 3 ) Ht (%) Hb (g/dL) WBC (mil/mm 3 )
reference values* 0–200 until 50 until 130 until 40 until 1.5 – 2 5 – 8 37 – 54 12 – 18 6 – 15,000
FC**          
FT1-S **          
FT2-IM 35,712 764 8 35 0.4 6.1 41 13.1 14,000
MC 41,920 376 49 48 0.6 5.6 36 13 20,000
MT1-S 40,384 604 41 34 0.5 5.2 33 12 18,000
MT2- IM*** 9,280 208 33 50 0.7 5.1 34 11.7 15,000
GRMD Control Data (n:6) 35,710 551 43.25 35.75 0.52 5.75 37.75 12.87 14,6
Normal Dogs Data (n: 6) 145 15 82 28 1.8 4.2 30.7 14.2 11,7
  1. Also, control dogs were used from all colony animals (Normal X Affected)
  2. *Reference values from Veterinary Hospital (HOVET) – FMVZ-USP and FMVZ-UNESP, São Paulo, Brazil.
  3. ** Animal died with 10 months (FC) and 8 months (FT1-S) *** Animal died with 13 months