Skip to main content

Table 3 Top 70 down-regulated genes

From: Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China

No. Gene symbol False discovery rate Fold difference Description
1 HERC3 < 1e-07 0.10 hect domain and RLD 3
2 PDCD4 < 1e-07 0.10 programmed cell death 4 (neoplastic transformation inhibitor)
3 SFRS5 < 1e-07 0.11 splicing factor, arginine/serine-rich 5
4 ST6GAL1 < 1e-07 0.13 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
5 DXYS155E < 1e-07 0.16 DNA segment on chromosome X and Y (unique) 155 expressed sequence
6 KIAA1641 < 1e-07 0.17 KIAA1641
7 LEPROTL1 < 1e-07 0.17 leptin receptor overlapping transcript-like 1
8 ELL2 < 1e-07 0.23 elongation factor, RNA polymerase II, 2
9 FUSIP1 < 1e-07 0.24 FUS interacting protein (serine-arginine rich) 1
10 OGT < 1e-07 0.24 O-linked N-acetylglucosamine (GlcNAc) transferase
11 MYST4 < 1e-07 0.26 MYST histone acetyltransferase (monocytic leukemia) 4
12 RUVBL2 0.0000063 0.13 RuvB-like 2 (E. coli)
13 ARF6 0.0000063 0.13 ADP-ribosylation factor 6
14 ACTR2 0.0000063 0.14 ARP2 actin-related protein 2 homolog (yeast)
15 TRIM23 0.0000063 0.15 tripartite motif-containing 23
16 HDAC3 0.0000063 0.15 histone deacetylase 3
17 PRKAR1A 0.0000063 0.17 protein kinase, cAMP-dependent, regulatory, type I, alpha
18 DR1 0.0000063 0.18 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
19 MAP4K3 0.0000063 0.21 mitogen-activated protein kinase kinase kinase kinase 3
20 PPP1CB 0.0000063 0.21 protein phosphatase 1, catalytic subunit, beta isoform
21 SEL1L 0.0000063 0.24 sel-1 suppressor of lin-12-like (C. elegans)
22 RAD17 0.0000063 0.24 RAD17 homolog (S. pombe)
23 ABI1 0.0000063 0.27 abl-interactor 1
24 ATM 0.0000063 0.27 ataxia telangiectasia mutated (includes complementation groups A, C and D)
25 STK17A 0.0000063 0.28 serine/threonine kinase 17a (apoptosis-inducing)
26 PRR4 0.0000094 0.02 proline rich 4 (lacrimal)
27 CHL1 0.0000094 0.06 cell adhesion molecule with homology to L1CAM (close homolog of L1)
28 PRKACB 0.0000094 0.10 protein kinase, cAMP-dependent, catalytic, beta
29 ELF1 0.0000094 0.13 E74-like factor 1 (ets domain transcription factor)
30 EPS15 0.0000094 0.16 epidermal growth factor receptor pathway substrate 15
31 NKTR 0.0000094 0.20 natural killer-tumor recognition sequence
32 DNAJC10 0.0000094 0.21 DnaJ (Hsp40) homolog, subfamily C, member 10
33 RARB 0.0000094 0.25 retinoic acid receptor, beta
34 FBXO9 0.0000094 0.29 F-box protein 9
35 MSMBROCK1 0.0000120 0.13 microseminoprotein, beta-
36 TADA3L 0.0000120 0.14 Rho-associated, coiled-coil containing protein kinase 1
37 TNFAIP8 0.0000120 0.16 transcriptional adaptor 3 (NGG1 homolog, yeast)-like
38 TGFBR2 0.0000120 0.16 tumor necrosis factor, alpha-induced protein 8
39 SLC23A1 0.0000120 0.19 transforming growth factor, beta receptor II (70/80 kDa)
40 FOXO1A 0.0000120 0.20 solute carrier family 23 (nucleobase transporters), member 1
41 USP12 0.0000120 0.20 forkhead box O1A (rhabdomyosarcoma)
42 CD2AP 0.0000134 0.18 ubiquitin specific protease 12
43 UBE4A 0.0000134 0.18 CD2-associated protein
44 SCP2 0.0000134 0.21 ubiquitination factor E4A (UFD2 homolog, yeast)
45 CAPN7 0.0000134 0.23 sterol carrier protein 2
46 PTPRS 0.0000134 0.24 calpain 7
47 BCL6 0.0000134 0.25 protein tyrosine phosphatase, receptor type, S
48 AGA 0.0000134 0.32 B-cell CLL/lymphoma 6 (zinc finger protein 51)
49 PROS1 0.0000134 0.33 aspartylglucosaminidase
50 UBL3 0.0000155 0.06 protein S (alpha)
51 BRF1 0.0000155 0.12 ubiquitin-like 3
52 ANP32B 0.0000155 0.15 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB
53 AMY2B 0.0000155 0.25 acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
54 FUBP3 0.0000167 0.07 amylase, alpha 2B; pancreatic
55 MAN2A1 0.0000167 0.15 far upstream element (FUSE) binding protein 3
56 TERF2IP 0.0000167 0.21 mannosidase, alpha, class 2A, member 1
57 PRKRIR 0.0000167 0.24 telomeric repeat binding factor 2, interacting protein
58 HRB2 0.0000167 0.27 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
59 MAP4K5 0.0000167 0.28 HIV-1 rev binding protein 2
60 PPM1B 0.0000184 0.16 mitogen-activated protein kinase kinase kinase kinase 5
61 PSIP1 0.0000184 0.16 protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform
62 TMEM1 0.0000184 0.18 PC4 and SFRS1 interacting protein 1
63 CDK5R1 0.0000184 0.31 transmembrane protein 1
64 ZA20D2 0.0000203 0.27 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
65 AIM2 0.0000216 0.14 zinc finger, A20 domain containing 2
66 NBR1 0.0000216 0.19 absent in melanoma 2
67 TCN1 0.0000216 0.26 neighbor of BRCA1 gene 1
68 STXBP3 0.0000225 0.20 transcobalamin I (vitamin B12 binding protein, R binder family)
69 ZNF265 0.0000225 0.20 syntaxin binding protein 3
70 HERC3 0.0000240 0.24 zinc finger protein 265