Table 3 Top 70 down-regulated genes

1

HERC3

< 1e-07

0.10

hect domain and RLD 3

2

PDCD4

< 1e-07

0.10

programmed cell death 4 (neoplastic transformation inhibitor)

3

SFRS5

< 1e-07

0.11

splicing factor, arginine/serine-rich 5

4

ST6GAL1

< 1e-07

0.13

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

5

DXYS155E

< 1e-07

0.16

DNA segment on chromosome X and Y (unique) 155 expressed sequence

6

KIAA1641

< 1e-07

0.17

KIAA1641

7

LEPROTL1

< 1e-07

0.17

leptin receptor overlapping transcript-like 1

8

ELL2

< 1e-07

0.23

elongation factor, RNA polymerase II, 2

9

FUSIP1

< 1e-07

0.24

FUS interacting protein (serine-arginine rich) 1

10

OGT

< 1e-07

0.24

O-linked N-acetylglucosamine (GlcNAc) transferase

11

MYST4

< 1e-07

0.26

MYST histone acetyltransferase (monocytic leukemia) 4

12

RUVBL2

0.0000063

0.13

RuvB-like 2 (E. coli)

13

ARF6

0.0000063

0.13

ADP-ribosylation factor 6

14

ACTR2

0.0000063

0.14

ARP2 actin-related protein 2 homolog (yeast)

15

TRIM23

0.0000063

0.15

tripartite motif-containing 23

16

HDAC3

0.0000063

0.15

histone deacetylase 3

17

PRKAR1A

0.0000063

0.17

protein kinase, cAMP-dependent, regulatory, type I, alpha

18

DR1

0.0000063

0.18

down-regulator of transcription 1, TBP-binding (negative cofactor 2)

19

MAP4K3

0.0000063

0.21

mitogen-activated protein kinase kinase kinase kinase 3

20

PPP1CB

0.0000063

0.21

protein phosphatase 1, catalytic subunit, beta isoform

21

SEL1L

0.0000063

0.24

sel-1 suppressor of lin-12-like (C. elegans)

22

RAD17

0.0000063

0.24

RAD17 homolog (S. pombe)

23

ABI1

0.0000063

0.27

abl-interactor 1

24

ATM

0.0000063

0.27

ataxia telangiectasia mutated (includes complementation groups A, C and D)

25

STK17A

0.0000063

0.28

serine/threonine kinase 17a (apoptosis-inducing)

26

PRR4

0.0000094

0.02

proline rich 4 (lacrimal)

27

CHL1

0.0000094

0.06

cell adhesion molecule with homology to L1CAM (close homolog of L1)

28

PRKACB

0.0000094

0.10

protein kinase, cAMP-dependent, catalytic, beta

29

ELF1

0.0000094

0.13

E74-like factor 1 (ets domain transcription factor)

30

EPS15

0.0000094

0.16

epidermal growth factor receptor pathway substrate 15

31

NKTR

0.0000094

0.20

natural killer-tumor recognition sequence

32

DNAJC10

0.0000094

0.21

DnaJ (Hsp40) homolog, subfamily C, member 10

33

RARB

0.0000094

0.25

retinoic acid receptor, beta

34

FBXO9

0.0000094

0.29

F-box protein 9

35

MSMBROCK1

0.0000120

0.13

microseminoprotein, beta-

36

TADA3L

0.0000120

0.14

Rho-associated, coiled-coil containing protein kinase 1

37

TNFAIP8

0.0000120

0.16

transcriptional adaptor 3 (NGG1 homolog, yeast)-like

38

TGFBR2

0.0000120

0.16

tumor necrosis factor, alpha-induced protein 8

39

SLC23A1

0.0000120

0.19

transforming growth factor, beta receptor II (70/80 kDa)

40

FOXO1A

0.0000120

0.20

solute carrier family 23 (nucleobase transporters), member 1

41

USP12

0.0000120

0.20

forkhead box O1A (rhabdomyosarcoma)

42

CD2AP

0.0000134

0.18

ubiquitin specific protease 12

43

UBE4A

0.0000134

0.18

CD2-associated protein

44

SCP2

0.0000134

0.21

ubiquitination factor E4A (UFD2 homolog, yeast)

45

CAPN7

0.0000134

0.23

sterol carrier protein 2

46

PTPRS

0.0000134

0.24

calpain 7

47

BCL6

0.0000134

0.25

protein tyrosine phosphatase, receptor type, S

48

AGA

0.0000134

0.32

B-cell CLL/lymphoma 6 (zinc finger protein 51)

49

PROS1

0.0000134

0.33

aspartylglucosaminidase

50

UBL3

0.0000155

0.06

protein S (alpha)

51

BRF1

0.0000155

0.12

ubiquitin-like 3

52

ANP32B

0.0000155

0.15

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB

53

AMY2B

0.0000155

0.25

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

54

FUBP3

0.0000167

0.07

amylase, alpha 2B; pancreatic

55

MAN2A1

0.0000167

0.15

far upstream element (FUSE) binding protein 3

56

TERF2IP

0.0000167

0.21

mannosidase, alpha, class 2A, member 1

57

PRKRIR

0.0000167

0.24

telomeric repeat binding factor 2, interacting protein

58

HRB2

0.0000167

0.27

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

59

MAP4K5

0.0000167

0.28

HIV-1 rev binding protein 2

60

PPM1B

0.0000184

0.16

mitogen-activated protein kinase kinase kinase kinase 5

61

PSIP1

0.0000184

0.16

protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform

62

TMEM1

0.0000184

0.18

PC4 and SFRS1 interacting protein 1

63

CDK5R1

0.0000184

0.31

transmembrane protein 1

64

ZA20D2

0.0000203

0.27

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

65

AIM2

0.0000216

0.14

zinc finger, A20 domain containing 2

66

NBR1

0.0000216

0.19

absent in melanoma 2

67

TCN1

0.0000216

0.26

neighbor of BRCA1 gene 1

68

STXBP3

0.0000225

0.20

transcobalamin I (vitamin B12 binding protein, R binder family)

69

ZNF265

0.0000225

0.20

syntaxin binding protein 3

70

HERC3

0.0000240

0.24

zinc finger protein 265