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Table 2 Percentage of CMV-antigen specific interferon gamma (IFN-γ) producing CD4+ and CD8+ T-cells in healthy donors and kidney transplant patients.

From: Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients

   Kidney transplant (KT) patients Healthy donors (HD)
    CMV D+R+/D-R+
n = 48, m = 79
CMV D+R-
n = 25, m = 50
p-values* CMV seropositive
n = 13, m = 19
CMV seronegative
n = 17, m = 17
p-values*
CMV- CD3+ CD4+ median (range) 0.05 (0.00–4.35) 0.01 (0.00–0.14) < 0.001 1.03 (0.03–6.19) 0.01 (0.00–0.22) < 0.001
lysate CD3+ CD8+ median (range) 0.02 (0.00–1.31) 0.00 (0.00–0.07) 0.003 0.49 (0.00–4.57) 0.00 (0.00–0.56) < 0.001
pp72 CD3+ CD4+ median (range) 0.04 (0.00–0.36) 0.02 (0.00–0.26) 0.027 0.08 (0.01–2.83) 0.00 (0.00–0.03) 0.001
peptides CD3+ CD8+ median (range) 0.05 (0.00–0.68) 0.03 (0.00–0.34) 0.056 0.2 (0.00–3.47) 0.00 (0.00–0.03) 0.002
pp65 CD3+ CD4+ median (range) 0.02 (0.00–0.50) 0.01 (0.00–0.55) 0.013 0.11 (0.00–4.70) 0.00 (0.00–0.02) 0.018
peptides CD3+ CD8+ median (range) 0.02 (0.00–0.62) 0.00 (0.00–0.25) 0.001 0.21 (0.00–2.80) 0.00 (0.00–0.20) 0.009
  1. Note. The results are given as frequencies of CD3+ CD4+ or CD3+CD8+ lymphocytes as detailed in Materials&Methods. The number of measurements exceeds the number of patients because some patients were tested at more than one visit. CMV, Cytomegalovirus; HD, healthy donors; KT, kidney transplant; n, number of patients; m, number of independent blood sampling and measurements. CMV seronegative KT patients had a D(+)R(-) constellation. CMV seropositive KT patients included both D(+)R(+) and D(-)R(+) constellations. (*) Mann-Whitney U test.