From: Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients
CMV D+R- | CMV D+R+/D-R+ | |||||
---|---|---|---|---|---|---|
Initial CMV replication | all | yes | no | all | yes | no |
numbera | 25 | 9 | 16 | 48 | 6 | 42 |
Age, median years (range) | 60 (18–71) | 63 (25–71) | 59 (18–71) | 49 (21–73) | 53 (43–70) | 43 (21–73) |
Gender (m/f) | 15/10 | 6/3 | 9/7 | 33/15 | 5/1 | 28/14 |
Sample date, weeks postTx median (range) | 18 (2–383) | 30 (6–41) | 15 (2–383) | 27 (2–314) | 21 (5–138) | 17 (2–314) |
Induction (%) | 19 (76.0%) | 7 (77.8%) | 12 (54.5%) | 36 (75.0%) | 3 (50.0%) | 33 (76.7%) |
T-cell depleting induction (%) | 1 (4.0%) | 0 (0.0%) | 1 (4.5%) | 4 (8.3%) | 0 (0.0%) | 4 (9.3%) |
AR therapy (%) | 8 (32.0%) | 2 (22.2%) | 6 (27.3%) | 21 (43.8%) | 3 (50.0%) | 18 (41.9%) |
T-cell depleting AR therapy (%) | 3 (12.0%) | 0 (0.0%) | 3 (13.6%) | 11 (22.9%) | 2 (33.3%) | 9 (20.9%) |
Initial CMV load, mean (c/ml)a | - | 109'900 | < 300 | - | 49'588 | < 300 |
Initial CMV peak, mean (c/ml) | - | 181'811 | < 300 | - | 90'009 | < 300 |
Later CMV replication (n/total)b | - | 1/9 | 5/16 | - | 1/6 | 7/42 |
Later CMV load, mean (c/ml) | - | 288'001 | 9'323 | - | 1'489 | 72'581 |
Later CMV peak, mean (c/ml) | - | 1'240'000 | 37'260 | - | 3'387 | 311'071 |