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Table 1 Characteristics of CMV replicating and non-replicating kidney transplant patients.

From: Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients

 

CMV D+R-

CMV D+R+/D-R+

Initial CMV replication

all

yes

no

all

yes

no

numbera

25

9

16

48

6

42

Age, median years (range)

60 (18–71)

63 (25–71)

59 (18–71)

49 (21–73)

53 (43–70)

43 (21–73)

Gender (m/f)

15/10

6/3

9/7

33/15

5/1

28/14

Sample date, weeks postTx median (range)

18 (2–383)

30 (6–41)

15 (2–383)

27 (2–314)

21 (5–138)

17 (2–314)

Induction (%)

19 (76.0%)

7 (77.8%)

12 (54.5%)

36 (75.0%)

3 (50.0%)

33 (76.7%)

T-cell depleting induction (%)

1 (4.0%)

0 (0.0%)

1 (4.5%)

4 (8.3%)

0 (0.0%)

4 (9.3%)

AR therapy (%)

8 (32.0%)

2 (22.2%)

6 (27.3%)

21 (43.8%)

3 (50.0%)

18 (41.9%)

T-cell depleting AR therapy (%)

3 (12.0%)

0 (0.0%)

3 (13.6%)

11 (22.9%)

2 (33.3%)

9 (20.9%)

Initial CMV load, mean (c/ml)a

-

109'900

< 300

-

49'588

< 300

Initial CMV peak, mean (c/ml)

-

181'811

< 300

-

90'009

< 300

Later CMV replication (n/total)b

-

1/9

5/16

-

1/6

7/42

Later CMV load, mean (c/ml)

-

288'001

9'323

-

1'489

72'581

Later CMV peak, mean (c/ml)

-

1'240'000

37'260

-

3'387

311'071

  1. Note. Cytomegalovirus (CMV) seronegative KT patients had a D+R- serostatus. CMV seropositive KT patients were D+R+ or D-R+. AR, acute rejection; ATG, anti-thymoglobuline.
  2. a Patients are grouped according to CMV replication at initial time-point of testing PCR and T-cell responses and denoted as initial CMV episode.
  3. b Positive PCR testing detected during follow-up was denoted as later CMV episode.