Figure 1

White blood cell recovery profiles for vehicle, G-CSF, IL-12 pre-only, IL-12 post-only and IL-12 pre-post treatment groups following radiation (625 rad). White blood cell recovery profiles are shown for the EL4 tumor model (left; A, C and E) and the Lewis lung cancer model (right; B, D, and F) for neutrophils (A and B), lymphocytes (C and D) and monocytes (E and F). Pre-radiation blood values reflect an average of all animals in both groups (70 mice) before radiation and tumor inoculation. The normal threshold values for neutrophil, lymphocyte and monocyte counts in C57BL/6 mice are indicated. Following the initial dose of vehicle or cytokine, 4 subsequent doses were given every 3–4 days following radiation. IL-12 treated mice received a total dose (5 single doses) of 220 ng, whereas G-CSF treated mice received a total dose (5 single doses) of 5 μg.