TY - JOUR AU - Beano, Alessandra AU - Signorino, Elena AU - Evangelista, Andrea AU - Brusa, Davide AU - Mistrangelo, Marinella AU - Polimeni, Maria Antonia AU - Spadi, Rosella AU - Donadio, Michela AU - Ciuffreda, Libero AU - Matera, Lina PY - 2008 DA - 2008/05/16 TI - Correlation between NK function and response to trastuzumab in metastatic breast cancer patients JO - Journal of Translational Medicine SP - 25 VL - 6 IS - 1 AB - Trastuzumab is a monoclonal antibody selectively directed against Her2 and approved for the treatment of Her2 overexpressing breast cancer patients. Its proposed mechanisms of action include mediation of antibody-dependent cellular cytotoxicity (ADCC) by triggering FcγRIII on natural killer (NK) cells. This study addresses the correlation between overall NK function and trastuzumab's clinical activity. SN - 1479-5876 UR - https://doi.org/10.1186/1479-5876-6-25 DO - 10.1186/1479-5876-6-25 ID - Beano2008 ER -