Figure 2From: Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanomaClinical response to tremelimumab. (A) Baseline picture of patient 1111 intransit metastases, which were progressing after experimental therapy with an antiangiogenic agent. (B) Follow-up picture 5 months after initial dosing while receiving monthly tremelimumab at 10 mg/kg. (C) Dot plot of MHC tetramer analysis taken from peripheral blood at cycle 3. (D) Dot plot of MHC tetramer analysis of tumor infiltrating lymphocytes from a tumor biopsy of a regressing melanoma lesion at cycle 3. MHC = Major histocompatibility complex.Back to article page