Lung function. (A) Average pressure/Volume curves from naïve and AdTGF-β1 exposed rats. The curves from fibrotic animals demonstrate marked shifts downward and to the right, indicating stiffer lungs. Note: The upward deviation of the curve at day 14 at pressures above 60 cm H2O reflect the upper limits of the pressure transducer. (B) The parameter K was reduced at all time-points. (C) Lung stiffness was derived from the PV loop in Figure 4A and characterized as the volume of air needed to reach a pressure of 20 cm H2O. All values are given as mean, SE, n = 4–6 per group.