Skip to main content
Figure 2 | Journal of Translational Medicine

Figure 2

From: Merger of Ayurveda and Tissue Culture-Based Functional Genomics: Inspirations from Systems Biology

Figure 2

Molecular networks of crude extracts, withanone and withaferin A. (A) HPLC fractionation and characterization of the components with anti-tumor activities. LASH crude extract and withanone showed greater selectivity for tumor when assayed in parallel with normal cells. Details of the bioassays conducted are described in Widodo et al. [16]. (B) IPA-generated networks of the withanolides. Shaded node indicates that the gene was included in the input list of genes derived from siRNA/ribozyme screening. A solid line without arrow indicates protein-protein interaction. Arrows indicate the direction of action (either with or without binding) of one gene to another. (C) Pathway comparisons. Fisher's exact test was used at p = 0.05 level to determine whether a biological assignment could be explained by chance alone. Apparent from the canonical pathways, LASH statistically impacted on only three pathways, whereas the effects of withanone and withaferine A were more spread.

Back to article page