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Table 1 Promoter methylation status of MAL in cell lines of various tissues.

From: Hypermethylated MAL gene – a silent marker of early colon tumorigenesis

Cell line

Tissue

Promoter methylation status

Methylation frequency

BT-20

Breast

M

57%

BT-474

Breast

U/M

 

Hs 578T

Breast

U

 

SK-BR-3

Breast

U

 

T-47D

Breast

U/M

 

ZR-75-1

Breast

U

 

ZR-75-38

Breast

M

 

Co115

Colon

M

95%

HCT15

Colon

M

 

HCT116

Colon

M

 

LoVo

Colon

M

 

LS174T

Colon

M

 

RKO

Colon

M

 

SW48

Colon

M

 

TC7

Colon

M

 

TC71

Colon

M

 

ALA

Colon

M

 

Colo320

Colon

M

 

EB

Colon

M

 

FRI

Colon

U/M

 

HT29

Colon

M

 

IS1

Colon

M

 

IS2

Colon

M

 

IS3

Colon

M

 

LS1034

Colon

M

 

SW480

Colon

M

 

V9P

Colon

U

 

ACHN

Kidney

U

50%

Caki-1

Kidney

U

 

Caki-2

Kidney

M

 

786-O

Kidney

U/M

 

ES-2

Ovary

U/M

50%

OV-90

Ovary

U/M

 

Ovcar-3

Ovary

U

 

SK-OV-3

Ovary

U

 

AsPC-1

Pancreas

M

67%

BxPC-3

Pancreas

U

 

CFPAC-1

Pancreas

U

 

HPAF-II

Pancreas

M

 

PaCa-2

Pancreas

M

 

Panc-1

Pancreas

U/M

 

LNCaP

Prostate

U

0%

AN3 CA

Uterus

U/M

75%

HEC-1-A

Uterus

M

 

KLE

Uterus

U

 

RL95-2

Uterus

M

 
  1. The promoter methylation status of the individual cell lines was assessed by methylation-specific polymerase chain reaction (MSP). The methylation frequency reflects the number of methylated (M and U/M) samples from each tissue. Abbreviations: U, unmethylated; M, methylated.