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Table 5 Multivariate Cox proportional hazards regression model for the primary outcome in women without obstructive CAD*

From: Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation

Factor HR (95%CI) P
Clinical Model with Genetic Biomarkers (n = 396)
ADRB1 Gly389 carrier 1.71 (0.91–3.19) 0.09
ADRB3 Arg64 carrier 2.14 (1.06–4.30) 0.03
Black race 1.77 (0.90–3.48) 0.10
Age (per decade) 1.02 (0.99–1.05) 0.25
History of diabetes 4.08 (2.01–8.28) < 0.001
Ever-smoking 8.13 (3.55–18.63) < 0.001
Baseline systolic BP (per 10 mmHg) 1.16 (0.99–1.36) 0.06
Body mass index (per 5 kg/m2) 0.70 (0.54–0.92) 0.01
Clinical Model with Inflammatory and Genetic Biomarkers (n = 355)
ADRB1 Gly389 carrier 1.67 (0.85–3.27) 0.13
ADRB3 Arg64 carrier 2.43 (1.11–5.35) 0.03
Black race 1.84 (0.92–3.67) 0.08
Age (per decade) 1.01 (0.97–1.04) 0.66
History of diabetes 3.78 (1.78–8.02) < 0.001
Ever-smoking 7.43 (3.13–17.63) < 0.001
Baseline systolic BP (per 10 mmHg) 1.17 (0.98–1.37) 0.08
Body mass index (per 5 kg/m2) 0.70 (0.53–0.93) 0.01
1 inflammatory biomarker in upper quartile* 1.67 (0.75–3.77) 0.21
2 or 3 inflammatory biomarkers in upper quartile 4.30 (2.02–9.16) < 0.001
  1. Abbreviations: HR, hazard ratio; 95%CI, 95% confidence interval*
  2. * Hypertension and dyslipidemia eliminated from models after stepwise selection