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Table 4 Individual endpoint risk by ADRB1 and ADRB3 genotype

From: Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation

 

Death

Myocardial Infarction

Heart Failure

Stroke

 

No. Events (%)

Adjusted HR (95%CI)* n = 628

No. Events (%)

Adjusted HR (95%CI)* n = 628

No. Events (%)

Adjusted HR (95%CI)* n = 628

No. Events (%)

Adjusted HR (95%CI)* n = 628

All Patients (n = 628)

        

ADRB1 Arg389Gly

        

Arg/Arg

22 (7.3)

1.00 (reference)

4 (1.3)

1.00 (reference)

11 (3.6)

1.00 (reference)

14 (4.6)

1.00 (reference)

Arg/Gly

29 (10.8)

1.27 (0.73–2.23)

13 (4.8)

3.35 (1.08–10.3)

16 (6.0)

1.28 (0.58–2.80)

9 (3.4)

0.61 (0.26–1.41)

Gly/Gly

7 (13.0)

1.65 (0.68–3.99)

3 (5.6)

3.89 (0.84–18.1)

4 (7.4)

2.12 (0.65–6.91)

4 (7.4)

1.53 (0.49–4.77)

ADRB3 Trp64Arg †

        

Trp/Trp

50 (9.6)

1.00 (reference)

16 (3.1)

1.00 (reference)

24 (4.6)

1.00 (reference)

21 (4.0)

1.00 (reference)

Trp/Arg + Arg/Arg

10 (9.7)

1.01 (0.50–2.04)

4 (3.9)

1.47 (0.48–4.52)

6 (5.8)

1.46 (0.58–3.67)

5 (4.8)

1.20 (0.45–3.24)

Non-obstructive CAD (n = 400)

        

ADRB1

        

Arg389Gly

        

Arg/Arg

8 (4.1)

1.00 (reference)

0

1.00 (reference)

3 (1.5)

1.00 (reference)

5 (2.6)

1.00 (reference)

Arg/Gly

8 (4.8)

0.77 (0.29–2.05)

8 (4.8)

...

11 (6.6)

4.37 (1.12–17.0)

6 (3.6)

1.06 (0.31–3.66)

Gly/Gly

4 (11.1)

2.08 (0.60–7.18)

2 (5.6)

...

0

...

2 (5.6)

1.54 (0.29–8.31)

ADRB3

        

Trp64Arg †

        

Trp/Trp

17 (4.9)

1.00 (reference)

7 (2.1)

1.00 (reference)

11 (3.2)

1.00 (reference)

10 (2.9)

1.00 (reference)

Trp/Arg + Arg/Arg

4 (6.9)

1.91 (0.61–5.97)

3 (5.2)

2.94 (0.69–12.5)

3 (5.2)

2.10 (0.55–8.10)

3 (5.2)

2.35 (0.60–9.29)

  1. Abbreviations: HR, hazard ratio; 95%CI, 95% confidence interval
  2. * adjusted for age, race, presence of obstructive CAD, history of diabetes, ever-smoking, baseline systolic BP, BMI
  3. † analyzed using dominant model based on minor allele frequency ≤ 0.1