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Table 3 Incidence and relative hazard of primary outcome by genotype

From: Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation

Gene Genotype No. Events (%) Primary Outcome Incidence* All Patients Adjusted HR (95%CI) n = 628 P Whites Adjusted HR (95%CI) n = 524 P Blacks Adjusted HR (95%CI) n = 104 P
ADRB1          
Ser49Gly Ser/Ser 82 (18) 4.2 1.00 (reference)   1.00 (reference)   1.00 (reference)  
  Ser/Gly 30 (18) 3.8 0.88 (0.57–1.37) 0.58 0.89 (0.51–1.53) 0.66 1.12 (0.51–2.48) 0.78
  Gly/Gly 3 (33) 6.4 1.02 (0.31–3.36) 0.98 ... 0.98 1.95 (0.47–8.03) 0.36
Arg389Gly Arg/Arg 44 (15) 3.2 1.00 (reference)   1.00 (reference)   1.00 (reference)  
  Arg/Gly 55 (20) 4.5 1.15 (0.77–1.71) 0.49 1.09 (0.69–1.72) 0.71 1.23 (0.56–2.83) 0.62
  Gly/Gly 14 (26) 7.2 1.94 (1.05–3.59) 0.03 1.82 (0.92–3.61) 0.09 2.27 (0.53–9.79) 0.27
ADRB2          
Gly16Arg Gly/Gly 34 (18) 4.0 1.00 (reference)   1.00 (reference)   1.00 (reference)  
  Gly/Arg 57 (18) 4.0 0.93 (0.60–1.43) 0.73 0.90 (0.56–1.46) 0.67 1.09 (0.38–3.19) 0.87
  Arg/Arg 24 (21) 4.6 1.14 (0.67–1.93) 0.63 0.81 (0.42–1.57) 0.53 2.61 (0.81–8.42) 0.11
Gln27Glu Gln/Gln 52 (20) 4.4 1.00 (reference)      
  Gln/Glu 49 (17) 3.8 0.88 (0.59–1.30) 0.51 1.06 (0.67–1.71) 0.79 0.51 (0.20–1.30) 0.16
  Glu/Glu 14 (18) 4.4 0.99 (0.53–1.84) 0.98 1.13 (0.59–2.15) 0.72 ... 0.99
ADRB3          
Trp64Arg Trp/Trp 93 (18) 4.0 1.00 (reference)   1.00 (reference)   1.00 (reference)  
  Trp/Arg + Arg/Arg 21 (20) 4.8 1.32 (0.81–2.14) 0.26 1.19 (0.67–2.14) 0.55 1.33 (0.51–3.50) 0.56
ADRA1A          
Arg347Cys Arg/Arg 31 (18) 4.1 1.00 (reference)   1.00 (reference)   1.00 (reference)  
  Arg/Cys 58 (19) 4.4 1.03 (0.66–1.62) 0.88 0.97 (0.60–1.57) 0.89 1.05 (0.20–5.43) 0.95
  Cys/Cys 26 (18) 3.5 0.68 (0.37–1.18) 0.16 0.83 (0.43–1.58) 0.56 0.46 (0.08–2.39) 0.35
GNAS          
393 T > C T/T 36 (18) 3.9 1.00 (reference)   1.00 (reference)   1.00 (reference)  
  T/C 58 (20) 4.5 1.10 (0.71–1.69) 0.67 1.26 (0.73–2.17) 0.40 0.97 (0.39–1.93) 0.74
  C/C 21 (16) 3.6 1.31 (0.74–2.31) 0.36 1.60 (0.85–3.01) 0.15 ... 0.99
GNB3          
825 C > T C/C 47 (16) 3.7 1.00 (reference)   1.00 (reference)   1.00 (reference)  
  C/T 42 (18) 3.8 1.06 (0.69–1.64) 0.78 1.26 (0.73–2.17) 0.40 0.87 (0.40–1.93) 0.74
  T/T 26 (26) 6.1 1.51 (0.82–2.77) 0.19 1.60 (0.85–3.01) 0.15 ... 0.99
  1. Abbreviations: HR, hazard ratio; 95%CI, 95% confidence interval
  2. * incidence per 100 patient-years
  3. adjusted for age, race, presence of obstructive CAD, history of diabetes, ever-smoking, baseline systolic BP, BMI
  4. analyzed using dominant model based on minor allele frequency ≤ 0.1