|
Inoculum type
|
Recipients
|
First day Symptoms observed post BMT
|
#affected
|
% affected
|
Treatment
|
Rads (cGy)
|
Irradiator
|
|---|
|
BM+ Tc
|
B6 (Ly5.1)
|
6
|
2/4
|
50
| |
1300 split
|
Xray
|
|
BM + splenocytes
|
B6 (Ly5.1)
|
7
|
2/4
|
50
| |
1100 single
|
Xray
|
|
BM + Tc
|
B6 (Ly5.1)
|
9
|
2/4
|
50
| |
1100 single
|
Xray
|
|
BM+Tc
|
B6 (Ly5.1)
|
7
|
1/3
|
33
|
EL-4
|
1100 single
|
Xray
|
|
BM+Tc
|
B6 (Ly5.1)
|
7
|
3/12
|
25
|
EL-4
|
1100 single
|
Xray
|
|
BM+T c
|
B6 (Ly5.1)
|
6
|
2/6
|
33
|
EL-4
|
1100 single
|
Xray
|
|
BM+Tc
|
B6 (Ly5.1)
|
6
|
8/8
|
100
|
EL-4
|
1100 single
|
Xray
|
|
BM+Tc
|
B6 (Ly5.1)
|
6
|
11/20
|
55
| |
1100 single
|
gamma
|
|
BM+Tc
|
B6 (Ly5.1)
|
6
|
2/4
|
50
| |
1100 single
|
gamma
|
|
BM+Tc
|
B6 (Ly5.1)
|
6
|
4/5
|
80
| |
1100 split
|
gamma
|
|
BM+Tc
|
B6 (Ly5.1)
|
5
|
4/6
|
66
| |
1300 split
|
gamma
|
|
BM+Tc
|
B6 (Ly5.1)
|
5
|
9/11
|
81
|
MBL-2
|
1300 split
|
gamma
|
|
BM+DC
|
B6 (Ly5.1)
|
4
|
5/5
|
100
|
DC
|
1100 single
|
X-ray
|
|
BM+Tc
|
B6 (Ly5.1)
|
5
|
5/5
|
100
| |
1100 single
|
gamma
|
|
BM+Tc
|
B6 (Ly5.1)
|
5
|
3/9
|
33
| |
1000 single
|
gamma
|
- C57BL/6NCr underwent BMT and exhibited unexpected deaths. Animals were reconstituted with bone marrow (BM) and T-cells (Tc), or bulk splenocytes (splenocytes) or dendritic cells (DC). Symptoms started as early as day +4 post-transplantation. Some animals received MBL-2 or EL-4 leukemia cells. Ionizing radiation was given in a single or fractionated (split) dose or administered with an X-ray diffraction instrument. Split regimens were delivered in two equal amounts separated at least 3 hours apart.
