CD8 apoptosis may be a predictor of T cell number normalization after immune reconstitution in HIV

Table 5 CD8 Annexin V Levels at Baseline and 6 Years.

% Annexin V levels (mean ± SD)	CD4 (cells/mm³)			CD8(cells/mm³)			CD4:CD8 Ratio
	Baseline	6 YR	P-value	Baseline	6 YR	P-value	Baseline	6 YR	P-value
Low 2.2 ± 2.1	625 ± 221	1209 ± 164	0.001	967 ± 386	915 ± 308	0.766	0.76 ± 0.4	1.55 ± 0.9	0.038
High 17.0 ± 6.0	527 ± 132	754 ± 320	0.098	1234 ± 660	1172 ± 456	0.728	0.56 ± 0.36	0.7 ± 0.34	0.215

A repeated measures ANOVA showed a significant difference in the low annexin group for CD4 values from baseline to year 6 with a p value of p ≥ 0.001. The high annexin group CD4 values were not significant from baseline to year 6 with a p value of ≥ 0.098. CD8 values in both the low and high apoptosis groups were not significant for the baseline or 6 year analysis. The CD4:CD8 ratio for the low apoptosis group was significant with a p value of ≥ 0.038, but the ratio for the high apoptosis group was not significant (p ≥ 0.215) after 6 years.