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Table 5 CD8 Annexin V Levels at Baseline and 6 Years.

From: CD8 apoptosis may be a predictor of T cell number normalization after immune reconstitution in HIV

% Annexin V levels (mean ± SD) CD4 (cells/mm3) CD8(cells/mm3) CD4:CD8 Ratio
  Baseline 6 YR P-value Baseline 6 YR P-value Baseline 6 YR P-value
Low 2.2 ± 2.1 625 ± 221 1209 ± 164 0.001 967 ± 386 915 ± 308 0.766 0.76 ± 0.4 1.55 ± 0.9 0.038
High 17.0 ± 6.0 527 ± 132 754 ± 320 0.098 1234 ± 660 1172 ± 456 0.728 0.56 ± 0.36 0.7 ± 0.34 0.215
  1. A repeated measures ANOVA showed a significant difference in the low annexin group for CD4 values from baseline to year 6 with a p value of p ≥ 0.001. The high annexin group CD4 values were not significant from baseline to year 6 with a p value of ≥ 0.098. CD8 values in both the low and high apoptosis groups were not significant for the baseline or 6 year analysis. The CD4:CD8 ratio for the low apoptosis group was significant with a p value of ≥ 0.038, but the ratio for the high apoptosis group was not significant (p ≥ 0.215) after 6 years.