From: Cord blood in regenerative medicine: do we need immune suppression?
Disorder | Number Treated | Outcome | Ref. |
---|---|---|---|
Hurler's syndrome | 20 | 17 of the 20 children were alive a median of 905 days after transplantation, with complete donor chimerism and normal peripheral-blood alpha-L-iduronidase activity | [100] |
Duchenne muscular dystrophy | 1 | On 42nd day, physical examination revealed obviously improvement in walking, turning the body over, and standing up | [101] |
Malignant infantile osteopetrosis | 1 | Normalization of spine bone mineral density. | [102] |
Rothmund-Thomson syndrome | 1 | Complete immune reconstitution | [55] |
Buerger's disease | 4 | Ischemic rest pain suddenly disappeared. Digital capillaries were increased in number and size. | [84] |
Spinal Cord Injury | 1 | Improved sensory perception and movement in the SPI patient's hips and thighs within 41 days of cell transplantation. Regeneration of the spinal cord at the injured site | [85] |
Krabbe's disease | 25 | Progressive central myelination and continued gains in developmental skills, and most had age-appropriate cognitive function and receptive language skills in patient subset | [14] |
Omenn syndrome | 1 | T cell reconstitution | [103] |
Non-healing wounds | 2 | Accelerated healing | [86] |
Refractory anemia | 3 | All patients are alive and free of disease at between 17 and 39 months after cord blood administration | [104] |
Diamond-Blackfan anemia | 1 | Successful seroconversion to vaccines (diphtheria, pertussis, tetanus, rubella, measles, and BCG) administered 22–34 months post-transplant. | [105] |
Severe chronic active Epstein-Barr virus | 1 | Complete remission without circulating EBV-DNA has continued for 15 months transplant. | [106] |
Behcet's disease | 1 | Twenty-three months after CBT, the patient is doing well and has no signs or symptoms of Behcet's disease | [9] |
Mucopolysaccharidosis type IIB (Hunter syndrome) | 1 | Two years after transplant approximately 55% normal plasma iduronate sulfatase. activity has been restored and abnormal urinary excretion of glycosaminoglycans has nearly completely resolved. | [107] |