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Table 2 Association of SCIN-total-score with GST genotypes, age, and chemotherapy parameters by Ordinal Logistic Regression analysis

From: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study

Categorical variables

Symptoms class of SCIN-total-score

Univariate

Multiple†

GST genotype

Number (%)

No (0–5)

Moderate (6–9)

Severe (10–18)

P

OR (95% CI)

P

OR (95% CI)

P1

A/A

99 (41.6)

60 (60.6)

23 (23.2)

16 (16.2)

0.098

2.03 (0.88–4.67)

0.012

3.84 (1.34–10.75)

 

A/G

102 (42.9)

53 (52.0)

29 (28.4)

20 (19.6)

0.014

2.83 (1.24–6.46)

0.003

4.95 (1.70–14.45)

 

G/G

37 (15.5)

27 (73.0)

10 (27.0)

0 (0)

Reference for GSTP1-AA and -AG

T1

+

201 (84.5)

118 (58.7)

51 (25.4)

32 (15.9)

0.770

1.11 (0.55–2.22)

0.714

1.17 (0.50–2.73)

 

- (ref.)

37 (15.5)

22 (59.5)

11 (29.7)

4 (10.8)

    

M1

+

134 (56.3)

79 (59.0)

35 (26.1)

20 (14.9)

0.947

0.98 (0.59–1.63)

0.166

1.56 (0.83–2.94)

 

- (ref.)

104 (43.7)

61 (58.7)

27 (26.0)

16 (15.4)

    

Continuous variables

TCSs N (%)

Median

Minimum

Maximum

    

Age at survey (OR for 10 years)

238 (100%)

42.3

22.7

73.4

0.008

1.40 (1.09–1.80)

0.002

1.70 (1.22–2.36)

OR*

Cisplatin

238 (100%)

397

81

1571

<0.001

1.35 (1.11–1.49)

0.014

1.35 (1.06–1.71)

 

Bleomycin

226 (95.0%)

142

0

212

0.040

1.65 (1.00–2.72)

0.078

1.43 (0.93–2.13)

 

Vinblastine

133 (55.9%)

9.9

0

51

0.535

1.49 (0.41–6.05)

0.319

0.23 (0.01–4.14)

 

Etoposide

92 (38.7%)

727

0

4934

0.092

1.00 (1.00–1.00)

0.918

1.00 (0.90–1.11)

  1. *cumulative dose steps: bleomycin (100.000 IE/m2), cisplatin (100 mg/m2).
  2. † Significant associations (bold), marginal significance (italics)