Table 1 Gene Ontology Classification of Imiquimod-Induced Genes in AK Lesions
From: Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream
Ontology | Genes in the Data1 | Annotated Genes2 | P-value3 | Increased Expression | Decreased Expression | Description of Processes and Specific Genes |
|---|---|---|---|---|---|---|
Total | 436 | 17479 | Â | 369 | 67 | Â |
Response to stimuli | 137 | 2475 | 2.13E-19 | 125 | 12 | defense response, response to external biotic stimuli including, pest and pathogens, antimicrobial, anti-fungal, anti-viral response |
Defense response | 105 | 1174 | 1.54E-40 | 102 | 3 | immune response, inflammatory response |
Immune response | 106 | 1020 | 3.05E-40 | 104 | 2 | cellular defense response, humoral defense response, antigen binding, pattern binding, cytokine synthesis, chemokine synthesis, antigen presentation processing, inflammatory response |
Response to stress | 68 | 1337 | 1.77E-12 | 63 | 5 | response to pest and pathogen, inflammatory response, response to virus, response to wounding |
Inflammatory response | 25 | 244 | 4.35E-11 | 25 | 0 | defensive reaction (by vertebrate tissue) to infection or injury |
Response to wounding | 39 | 395 | 3.72E-16 | 39 | 0 | defensive reaction (by vertebrate tissue) to physical injury |
Signal transduction | 123 | 3547 | 4.70E-06 | 95 | 17 | cytokine signaling, death receptor signaling, G-protein coupled receptor signaling, intigrin binding, MHC protein binding |
Receptor activity | 72 | 1914 | 1.80E-07 | 62 | 10 | chemokine receptors, pattern recognition receptors, immunoglobulin receptors, complement receptors, MHC I\MHCII receptors, scavenger receptors, Hematopoietin/interferon class (D200) receptors |
Antigen binding | 8 | 91 | 2.66E-03 | 8 | 0 | SCF1, IGLV2-14, LAG3, LILRA1, SLAMF1, TRA@, TRGC2, TAP2 |
Carbohydrate binding | 16 | 326 | 1.18E-03 | 14 | 2 | CCL8, CD69, CLEC4A, FCN1, FGFR2, GALNT7, HMMR, KLRC1/KLRC2, KLRF1, LGALS2, LGALS9, POSTN, PTN, SELL, SELPLG, SN |
Pattern binding | 10 | 159 | 4.58E-02 | 8 | 2 | CCL8, CD14, FGFR2, HMMR, POSTN, PTN, TLR2, TLR7, TLR8, TLR4 |
Cytokine receptors | 9 | 99 | 1.97E-04 | 9 | 0 | CCR5, CCR1, CD74, CSF2RB, CXCR4, IL10RA, IL1RL1, IL21R, TNFRSF1B |
Cytokines | 12 | 257 | 1.11E-04 | 11 | 1 | CCL3, CCL5, CCL8, CXCL5, CXCL10, CXCL11, CXCL12, CXCL16, TNFSF10, ECGF1, PTN, SLURP1 |
Immunoglobulin binding | 4 | 25 | 1.56E-03 | 4 | 0 | FCER1A, FCER1G, FCGR3B, 214511_x_at |
Cystein type endopeptidase | 9 | 169 | 8.21E-03 | 9 | 0 | CASP1, CASP8, CTSB, CTSL, CTSC, STSS, LGMN, TNFAIP3, USP18 |