Figure 1From: Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitisImmunohistochemistry of human chronic pancreatitis tissue specimens. Consecutive sections of chronic pancreatitis tissues were subjected to immunohistochemistry using antibodies against alphaSMA (A; SMA), vimentin (B; VIM), CD31 (C), CD45 (D), collagen1 (E; COL) and fibronectin (F; FBN). Arrows: area around packed clusters of mononuclear cells. Arrowheads in A-C: pancreatic stellate cells (SMA- and VIM-positive, CD31-negative). Arrowhead in D: loosely distributed area of mononuclear cell infiltration. Arrowhead in E&F: areas of less intense immunoreactivities for collagen1 and fibronectin. Dotted arrows: Areas of strong collagen1 and fibronectin staining. Original magnification: ×50. (G) Arrows: areas of loosely distributed/single mononuclear cells, dotted arrows: area without mononuclear cells. (H&I) Arrows/dotted arrows: corresponding areas to (G).Back to article page