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Figure 6 | Journal of Translational Medicine

Figure 6

From: A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo

Figure 6

339.1 inhibits angiogenesis and tumor growth in vivo. Mice bearing established SVR murine angiosarcoma, (A) or A673 human rhabdomyosarcoma tumors, (B), were treated with 339.1 (10 mg/kg, intraperitoneally, thrice or twice weekly, respectively) or vehicle control and tumor volume was monitored using vernier calipers. 339.1 inhibits tumor growth in vivo relative to control. Results were statistically significant in both settings. A673 tumors were resected from 339.1- and control-treated mice and frozen sections were assessed for vessel density by immunohistochemical staining for CD31, (C). Vessel density was significantly reduced in tumors from animals treated with 339.1, (D).

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