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Table 3 Antibody responses to vaccine, fowlpox and CEA

From: Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer

Patient No. Time point Titer   
   Anti-Vaccinia Anti-Fowlpox Anti-CEA
002-001 Day 0 1600 200 NDa
  Day 14 6400 - <100
  Day 28 - - <100
  Day 42 - - <100
  Day 70 - 3200 <100
  Extension Phase Month 1b - - <100
  Extension Phase Month 2 - - <100
002-002 Day 0 1600 <100 ND
  Day 14 3200 - <100
  Day 28 - - <100
  Day 42 - - <100
  Day 63 - 1600 <100
002–003 Day 0 400 <100 ND
  Day 14 1600 - <100
  Day 28 - <100 <100
  Day 36 - - ND
002–005 Day 0 200 <100 ND
  Day 14 800 - <100
  Day 28 - - <100
  Day 42 - - 100
  Day 70 - 400 <100
002–006 Day 0 200 <100 ND
  Day 14 800 - <100
  Day 28 - - <100
  Day 42 - - 3200
  Day 70 - 800 800
  Extension Phase Month 2 - - 800
  Extension Phase Month 3 - - 400
002–007 Day 0 <100 200 ND
  Day 14 200 - <100
  Day 28 - - <100
  Day 42 - - 100
  Day 70 - 800 100
  Extension Phase Month 2 - - <100
  Extension Phase Month 3 - - <100
  Extension Phase Month 4 - - <100
  Extension Phase Month 5 - - <100
  Extension Phase Month 6 - - <100
  Extension Phase Month 7 - - <100
  Extension Phase Month 8 - - <100
  Extension Phase Month 9 - - <100
001–008 Day 0 800 <100 ND
  Day 14 6400 - <100
  Day 28 - - <100
  Day 42 - 3200 <100
001–009 Day 0 800 <100 ND
  Day 14 800 - <100
  Day 28 - <100 <100
001–010 Day 0 400 <100 ND
  Day 14 1600 - <100
  Day 28 - - <100
  Day 42 - 100 100
001–011 Day 0 1600 100 ND
  Day 14 1600 - <100
  Day 28 - - <100
  Day 42 - - <100
  Day 70 - 800 200
  Extension Phase Month 2 - - 100
  1. Bolded values indicate development of antibody response, which is defined as a 2-fold increase in titer of the post-immunization sample as compared to the corresponding negative control sample. aND: not determined. Because the time 0 sample is the negative control sample for the CEA ELISA, a titer cannot be assigned to this sample. bFor this patient, the sample collected approximately 2 weeks after the day 70 vaccination was labeled "Extension Phase Month 1"; for all other patients, the sample collected one month after the day 70 vaccination was labeled "Extension Phase Month 2".