Figure 1

Increase in CD34⁺ cells in 14-day cultures with different doses of SCF, Flt3-L and G-CSF alone and in combination. (a) Responses of a representative patient's CD34⁺ cells to different combinations of SCF and Flt3-L showing the greatest increase with the combination of 100 ng/ml SCF and 10 ng/ml Flt3-L. (b) Responses of five different patients showing that in general 10 ng/ml Flt3-L gives a greater response than 100 ng/ml Flt3-L in combination with 100 ng/ml SCF. (c) Responses of a representative patient's CD34⁺ cells to 100 ng/ml SCF + 10 ng/ml Flt3-L added at day zero, alone or with 100 ng/ml G-CSF added at day zero or day 7. (d) Range of five patients' responses to 100 ng/ml SCF + 10 ng/ml Flt3-L + 100 ng/ml G-CSF (these are a different five patients from those shown in b).