Quantitative determination of PGE
levels in culture medium by ELISA assay. (A). Variations induced in WiDr and LoVo Dx cells by a 24-hour exposure to NS 398 (50 μM), NCX 4040 (50 μM), or both drugs. Apoptosis induction after inhibition of COX-2 enzyme (B). Percentage of apoptotic cells after exposure of WiDr and LRWZ cells to NS398, NCX 4040 or both drugs.