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Table 3 Summary of clinical and laboratory findings for Responders (1–16) and Non-responders (17–20).

From: Mycobacterium avium complex immune reconstitution inflammatory syndrome: Long term outcomes

  CD4 count (cells/ml)    Treatment
# Age, sex Symptoms Organ involvement Diagnostic procedure Baseline viral loada Baselineb At time of IRIS At time of follow upc Viral load at follow up Time to IRISd (days) MAC therapy Duration of corticosteroid (months)
1 37, F Fever, N/V GI, liver Liver biopsy 249,880 10 54 84 <50 226 Azm, ETB 12
2 40, M Fever, abd pain Abd LN LN aspirate 32,318 43 165 229 <50 66 Azm, ETB ---
3 44, M Fever, abd pain GI, Bone marrow BMBx, blood Cx 215,201 69 199 326 <50 25 Clm, ETB, RIB, cipro 22
4 59, M Fever, abd pain GI, Bone marrow GI biopsy, BMBx 188,000 34 98 140 <50 604 Azm, ETB, RIB, cipro 10
5 33, M LAN Axillary LN LN aspirate 72,777 20 64 89 <50 1689 Clm, ETB ---
6 53, M LAN Axillary LN Tissue culture 750,000 9 111 201 <50 306 Clm, ETB ---
7 53, M Fever, rash, NS Supraclavicular LN LN aspirate 31,517 5 142 97 <50 192 Azm, ETB, RIB ---
8 47, M Fever, abd pain, NS Supraclavicular LN, Liver Liver biopsy 500,000 2 3 13 21,439 122 Azm, ETB, RIB Not available
9 32, M LAN Cervical LN LN aspirate 117,580 204 224 403 <50 456 Clm, ETB, RIB ---
10 28, M LAN Axillary LN Tissue culture 217,174 8 66 226 <50 75 Clm, ETB, RIB ---
11 38, M Fever, Wt loss Liver, Bone marrow Liver Bx, BMBx 750,000 4 35 99 87 10 Clm, ETB ---
12 38, M Fever, LAN, fatigue Cervical LN Tissue culture 366,000 16 46 10 97,000 18 Azm, ETB, RIB ---
13 40, M Fever, abd pain, N/V, diarrhea Abd LN, GI LN aspirate 321,851 21 71 73 849 84 Azm, ETB 6
14 40, M Fever, diarrhea, cough ABD LN, Mediastinal LN Blood Cx, CT 624,697 1 18 48 <50 63 Clm, ETB, RIB 14
15 30, F Fever, NS, diarrhea GI, Bone marrow Tissue Bx, BMBx 205,115 9 39 141 336 16 Clm, ETB ---
16 42, F Fever, NS Abd LN Blood Cx, CT 2,115,623 7 65 118 2,729 17 Clm, ETB ---
17 46, M LAN, abd pain Abd LN, supraclavicular LN, mediastinal LN LN aspirate 292,571 11 72 108 <50 359 Azm, ETB, RIB, cipro, amikacin ---
18 44, M Fever, abd pain Abd LN LN aspirate 205,000 5 61 40 <50 360 Clm, ETB, RIB, cipro, amikacin 48
19 27, M Fever, abd pain, N/V GI, abd LN Blood Cx, CT 490,668 6 112 111 <50 47 Azm, ETB 7
20 35, M Fever, abd pain, N/V, diarrhea GI, abd LN Blood Cx, stool Cx, CT 48,053 2 364 3 70,324 13 Azm, ETB ---
  1. Note: N/V, nausea and vomiting; abd, abdominal; LAN, lymphadenopathy; NS, night sweats; GI, gastrointestinal tract; LN, lymph node; Cx, culture; BMBx, bone marrow biopsy; Bx, biopsy; CT, CAT scan findings; Azm, azithromycin; ETB, ethambutol; Clm, clarithromycin; RIB, rifabutin.
  2. a HIV quantitative PCR measured as copies/cc of plasma.
  3. b CD4 count prior to the initiation of HAART.
  4. c For responders, follow up = resolution of symptoms.
  5. d Duration of time from the initiation of HAART to the development of IRIS symptoms.