Skip to main content

Table 3 Autologous T helper responses to vaccines in cancer patients

From: Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells

Stimulation index
DC treatment Donor 1 Donor 2 Donor 3 Donor 4 Donor 5 Donor 6
Vaccine only 6 5.7 0.0 0.0 0.0 0.0
R-848 only 5.3 5.9 3.6 0.5 0.5 0.5
Vaccine + R -848 5.8 6.2 0.5 0.0 0.0 0.0
Poly IC only 5 5.9 5 5.8 0.0 0.6
Vaccine + Poly IC 5.8 6.0 4.8 6.0 0.0 0.0
Vaccine + R -848 + Poly IC 9.0 6.2 8.0 9.0 6.5 7.0
  1. T cell lines were derived from 6 different donors (all cancer patients) and generated by in vitro stimulation with autologous DCs. Briefly, DCs were first exposed to vaccine (B11-hCGβ) and further activated with R-848 and Poly I:C and T cells added to the mix. Proliferative responses were tested in a standard 5-day BrdU incorporation ELISA. Values are relative to unstimulated DCs.