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Table 1 Production of Th1-like cytokines by activated DCs

From: Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells

Immature Mo-DC Treatment Donor 4 Donor 5
No vaccine Vaccine No vaccine Vaccine No vaccine Vaccine No vaccine Vaccine
  IL-10 IL-10 IL-12p70 IL-12p70 IL-10 IL-10 IL-12p70 IL-12p70
None 43 ± 2 61 ± 10 145 ± 10 498 ± 23 30 ± 4 23 ± 10 115 ± 18 121 ± 11
Activated CD4+ T 46 ± 8 149 ± 3 189 ± 16 154 ± 12 60 ± 15 241 ± 3 234 ± 6 644 ± 6
CD40L XL 45 ± 3 211 ± 21 185 ± 40 4818 ± 18 136 ± 11 513 ± 9 1139 ± 24 1406 ± 6
LPS E.coli 171 ± 16 1041 ± 26 308 ± 11 1588 ± 1 10 415 ± 4 552 ± 11 1089 ± 19 1859 ± 60
Poly I:C * 184 ± 11 307 ± 6 2221 ± 210 8327 ± 240 308 ± 10 475 ± 24 1369 ± 58 2847 ± 36
MALP -2 87 ± 13 125 ± 12 7646 ± 110 169 ± 33 41 ± 12 574 ± 22 1512 ± 26 610 ± 11
Pam3CSK4 28 ± 4 81 ± 11 40 ± 7 430 ± 23 441 ± 22 691 ± 31 644 ± 15 797 ± 18
Flagellin 54 ± 6 26 ± 7 80 ± 30 335 ± 18 1211 ± 20 1406 ± 11 809 ± 11 4110 ± 51
Loxoribine 22 ± 11 72 ± 8 34 ± 16 1141 ± 9 691 ± 13 1106 ± 31 1839 ± 15 4293 ± 15
R-848 ** 12 ± 3 1106 ± 21 43 ± 10 4293 ± 228 667 ± 9 823 ± 11 983 ± 21 2103 ± 121