Table 1 Production of Th1-like cytokines by activated DCs
Immature Mo-DC Treatment | Donor 4 | Donor 5 | ||||||
|---|---|---|---|---|---|---|---|---|
No vaccine | Vaccine | No vaccine | Vaccine | No vaccine | Vaccine | No vaccine | Vaccine | |
| Â | IL-10 | IL-10 | IL-12p70 | IL-12p70 | IL-10 | IL-10 | IL-12p70 | IL-12p70 |
None | 43 ± 2 | 61 ± 10 | 145 ± 10 | 498 ± 23 | 30 ± 4 | 23 ± 10 | 115 ± 18 | 121 ± 11 |
Activated CD4+ T | 46 ± 8 | 149 ± 3 | 189 ± 16 | 154 ± 12 | 60 ± 15 | 241 ± 3 | 234 ± 6 | 644 ± 6 |
CD40L XL | 45 ± 3 | 211 ± 21 | 185 ± 40 | 4818 ± 18 | 136 ± 11 | 513 ± 9 | 1139 ± 24 | 1406 ± 6 |
LPS E.coli | 171 ± 16 | 1041 ± 26 | 308 ± 11 | 1588 ± 1 10 | 415 ± 4 | 552 ± 11 | 1089 ± 19 | 1859 ± 60 |
Poly I:C * | 184 ± 11 | 307 ± 6 | 2221 ± 210 | 8327 ± 240 | 308 ± 10 | 475 ± 24 | 1369 ± 58 | 2847 ± 36 |
MALP -2 | 87 ± 13 | 125 ± 12 | 7646 ± 110 | 169 ± 33 | 41 ± 12 | 574 ± 22 | 1512 ± 26 | 610 ± 11 |
Pam3CSK4 | 28 ± 4 | 81 ± 11 | 40 ± 7 | 430 ± 23 | 441 ± 22 | 691 ± 31 | 644 ± 15 | 797 ± 18 |
Flagellin | 54 ± 6 | 26 ± 7 | 80 ± 30 | 335 ± 18 | 1211 ± 20 | 1406 ± 11 | 809 ± 11 | 4110 ± 51 |
Loxoribine | 22 ± 11 | 72 ± 8 | 34 ± 16 | 1141 ± 9 | 691 ± 13 | 1106 ± 31 | 1839 ± 15 | 4293 ± 15 |
R-848 ** | 12 ± 3 | 1106 ± 21 | 43 ± 10 | 4293 ± 228 | 667 ± 9 | 823 ± 11 | 983 ± 21 | 2103 ± 121 |