Table 2 Belinostat induces 34 genes involved in cellular communication. Summary of fold changes in transgenic mice bladder gene expression for belinostat-treated versus control
Gene Name | Gene Symbol | Gene Function | Fold Change |
|---|---|---|---|
Adiponectin, C1Q and collagen domain containing | Adipoq | Cardiovascular, homeostasis | 3.1 |
Chemokine (C-C motif) ligand 2 | Ccl2 | Chemotaxis, immune response | 2.8 |
Secreted frizzled-related sequence protein 1 | Sfrp1 | Transmemb. receptor activity | 2.5 |
Metallothionein 2 | Mt2 | Binds metal ions | 1.8 |
Gap junction membrane channel protein alpha 1 | Gja1 | Intercellular channel | 1.1 |
Protein phosphatase 2A | Ppp2r2a | Intrinsic catalyst activity | 1 |
Early growth response 2 | Egr2 | DNA and metal ion binding | 1.2 |
Metallothionein 1 | Mt1 | Metal ion binding | 1.3 |
BMP-binding endothelial regulator | Bmper | Neg regulation of BMP pathway | 1 |
RAB2 | Rab2 | Member Ras oncogene family | 1 |
ADP-ribosylation factor 4 | Arf4 | GTP binding | 1 |
Cell division cycle 42 homolog | Cdc42 | GTP binding | 1 |
CD47 antigen | CD47 | Integrin-assoc. signal transducer | 1 |
Tyrosine 3-monooxygenase activation protein | Ywahz | Brain signal transduction | 1 |
Integrin beta 1 | Itgb1 | Fibronectin receptor beta | 1.1 |
Integrin linked kinase | Ilk | ATP binding, kinase activity | -1 |
Real guanine nucleotide dissociation stimulator-like 2 | RgI2 | Â | -1.1 |
Regulator of G-protein signaling 19 | Rgs19 | Neg regulation of signal transd. | -1.1 |
Reelin | Reln | Axon guidance, brain dev. | -1.2 |
Conserved helix-loop-helix ubiquitous kinase | Chuk | Morphogen. of epithelial sheet | -1.1 |
MKIAA1154 protein | Â | Â | -1.4 |
Diacylglycerol kinase zeta | Dgkz | Protein kinase C activation | -1.1 |
Phospholipase D2 | Pld2 | Catalytic activity | -1.2 |
PTK2 protein tyrosine kinase 2 | Ptk2 | Angiogenesis, blood vessel dev. | -1.7 |
5 days embryo whole body cDNA | Bmp4 | Bone | -1.2 |
Deltex 2 homolog | Dtx2 | Notch signaling pathway | -1.3 |
G protein-coupled receptor, family C, group 5, memb C | Gprc5C | Signal transduction | -1.4 |
Disheveled, dsh homolog 1 | Dvl1 | Dendrite morphogenesis | -1.2 |
Angiotensin receptor-like 1 | Agtrl1 | Signal transduction | -1.4 |
RAB2B | Rab2b | ER to golgi and protein transprt. | -1.1 |
Intersectin 1 | Itsn1 | Endocytosis, intracellular signal | -1.5 |
Ras and Rab interactor 1 | Rin1 | Endocytosis, intracellular signal | -1.4 |
Tripartite motif protein 9 | Trim9 | Synaptic vesicle exocytosis | -2.2 |
Casitas B-lineage lymphoma | Cbl | Ca ion binding, ligase activity | -4 |