Table 1 Belinostat induces P21WAF1 and other HDAC core genes in transgenic mice bladders. Summary of changes in transgenic mice bladder gene expression for belinostat-treated versus control
Gene Name | Gene Symbol | Gene Function | Fold Change |
|---|---|---|---|
Acidic nuclear phosphoprotein 32 family, member B | Anp32b | Cell cycle | 1.2 |
Clusterin | Clu | Cell death/apoptosis | -2.2 |
Cyclin-dependent kinase inhibitor 1A | P21 | Cell cycle regulation | 1.5 |
Cytidine 5'-triphosphate synthase | Ctps | DNA synthesis | 1.8 |
Dehydrogenase/reductase (SDR family) member 3 | Dhrs3 | Short chain alchol dehydrogenase | 1.3 |
Dehydrogenase/reductase (SDR family) member 4 | Dhrs4 | Short chain alchol dehydrogenase | -1.4 |
Dehydrogenase/reductase (SDR family) member 7 | Dhrs7 | Short chain alchol dehydrogenase | 1.3 |
Dehydrogenase/reductase (SDR family) member 8 | Dhrs8 | Short chain alchol dehydrogenase | 1.5 |
Fucosidase, alpha-L-1, tissue | Fuca1 | Proteoglycan metabolism | 1.6 |
Glutaredoxin 1 (thioltransferase) | Glrx1 | Glutathione dep DNA synthesis | 1.3 |
Glutaredoxin 2 (thioltransferase) | Glrx2 | Glutathione dep DNA synthesis | 1.2 |
Hepatoma-derived growth factor | hdgf | Transformation related protein | 1.3 |
Hepatoma-derived growth factor | hdgf | Transformation related protein | 2.9 |
Histone 2, H2be | Hist2h2bb | Nucelear organization | -1.6 |
Karyopherin (Importin) beta 1 | kpnb1 | Nucelear translocation | -1.6 |
Karyopherin (Importin) beta 1 | kpnb1 | Nucelear translocation | 1.1 |
Karyopherin (Importin) beta 1 | kpnb1 | Nucelear translocation | 1.4 |
Metalliothionine 1 | Mt1 | Binds heavy metals | 4.3 |
Tubulin, alpha 2 | Tuba2 | Cytoskeletal structure | 1.1 |
Tubulin, alpha 4 | Tuba4 | Cytoskeletal structure | -1.7 |
Tubulin, alpha 6 | Tuba6 | Cytoskeletal structure | -1.2 |
Tubulin, alpha 6 | Tuba6 | Cytoskeletal structure | 1.2 |