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Table 3 Testing results

From: Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles

 

Tubular Toxicity Test

with 4 veh positives

without 4 veh positives

TRUE

FALSE

TRUE

FALSE

Positive

38

7

38

7

Negative

74

9

74

5

Sn

81% = 38/(38 + 9)

88% = 38/(38 + 5)

Sp

91% = 74/(74 + 7)

91% = 74/(74 + 7)

Positive Prediction

84% = 38/(38 + 7)

84% = 38/(38 + 7)

Negative Prediction

89% = 74/(74 + 9)

94% = 74/(74 + 5)

  1. Linear SVM model was built using Merck studies as training set. Using Charles River Laboratories studies as testing set, sensitivity and specificity as well as Positive prediction of kidney proximal tubule toxicity classification were obtained.
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