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Table 3 Testing results

From: Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles

  Tubular Toxicity Test
with 4 veh positives without 4 veh positives
TRUE FALSE TRUE FALSE
Positive 38 7 38 7
Negative 74 9 74 5
Sn 81% = 38/(38 + 9) 88% = 38/(38 + 5)
Sp 91% = 74/(74 + 7) 91% = 74/(74 + 7)
Positive Prediction 84% = 38/(38 + 7) 84% = 38/(38 + 7)
Negative Prediction 89% = 74/(74 + 9) 94% = 74/(74 + 5)
  1. Linear SVM model was built using Merck studies as training set. Using Charles River Laboratories studies as testing set, sensitivity and specificity as well as Positive prediction of kidney proximal tubule toxicity classification were obtained.